Valproic acid in ultrarapid cycling: A case report

E. Lepkifker, I. Iancu, P. Dannon, R. Ziv, M. Kotler

Research output: Contribution to journalArticlepeer-review


Valproic acid has been proven to be efficient in the treatment of bipolar affective disorders as an adjunctive agent to lithium and carbamazepine. Recently, its efficacy in rapid cycling states has attracted interest. We present the case of a male patient with bipolar affective disorder who developed an extreme state of ultrarapid cycling (48-h cycles). Only the addition of valproic acid therapy to prior lithium treatment succeeded in curtailing the ultra-rapid cycling. Several issues regarding ultra-rapid cycling and valproate's efficacy in bipolar disorder are discussed.

Original languageEnglish
Pages (from-to)72-75
Number of pages4
JournalClinical Neuropharmacology
Issue number1
StatePublished - 1995
Externally publishedYes


  • Bipolar disorder
  • Ultrarapid cycling
  • Valproic acid


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