Validation of the Urticaria Control Test (UCT) in Children With Chronic Urticaria

Connor Prosty*, Sofianne Gabrielli, Pasquale Mule, Nuzha Noorah, Sharon Baum, Shoshana Greenberger, Luis F. Ensina, Xun Zhang, Elena Netchiporouk, Moshe Ben-Shoshan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Background: Few validated tools exist to evaluate chronic urticaria (CU) control in children. Although the Urticaria Control Test (UCT) exhibits favorable clinometric properties in adult CU, it is not yet validated in children. Objective: To evaluate the validity of the UCT for the assessment of pediatric CU. Methods: Children presenting with CU were consecutively recruited and completed both the UCT and the Children's Dermatology Life Quality Index (CDLQI) at study entry. Using the CDLQI as an anchor, we assessed the internal consistency, convergent and known-groups validity, and screening accuracy of the UCT at study entry and at follow-up. Results: A total of 52 children with CU were recruited. The UCT exhibited respectable internal consistency in the evaluation of CU (Cronbach's α, 0.73; 95% CI, 0.62-0.85). UCT and CDLQI scores strongly correlated (r = −0.74; P <.01). The UCT distinguished between different strata of disease severities established by the CDLQI (P <.01). Screening accuracy of the UCT was excellent in the discrimination of poorly controlled CU (area under the curve, 0.82). An optimal cutoff of less than or equal to 10 was determined for defining poorly controlled CU (sensitivity, 95.5%; specificity, 63.3%). Data at follow-up were consistent with data at study entry. Subgroup analyses of patients with chronic spontaneous urticaria were consistent with overall estimates of validity. Conclusions: The UCT is a valid tool for the assessment of pediatric CU and chronic spontaneous urticaria, as evidenced by the acceptable internal consistency, convergent and known-groups validity, and screening accuracy at multiple time points.

Original languageEnglish
Pages (from-to)3293-3298.e2
JournalJournal of Allergy and Clinical Immunology: In Practice
Volume10
Issue number12
DOIs
StatePublished - Dec 2022

Funding

FundersFunder number
Novartis and Sanofi
Novartis
AbbVie

    Keywords

    • Children's Dermatology Life Quality Index
    • Chronic urticaria
    • Disease control
    • Patient-reported outcome
    • Pediatric
    • Urticaria Control Test
    • Validity

    Fingerprint

    Dive into the research topics of 'Validation of the Urticaria Control Test (UCT) in Children With Chronic Urticaria'. Together they form a unique fingerprint.

    Cite this