TY - JOUR
T1 - Validation of proposed diagnostic criteria (the "budapest Criteria") for Complex Regional Pain Syndrome
AU - Harden, R. Norman
AU - Bruehl, Stephen
AU - Perez, Roberto S.G.M.
AU - Birklein, Frank
AU - Marinus, Johan
AU - Maihofner, Christian
AU - Lubenow, Timothy
AU - Buvanendran, Asokumar
AU - MacKey, Sean
AU - Graciosa, Joseph
AU - Mogilevski, Mila
AU - Ramsden, Christopher
AU - Chont, Melissa
AU - Vatine, Jean Jacques
N1 - Funding Information:
This project was supported by a Grant from the Reflex Sympathetic Dystrophy Syndrome Association (RSDSA), with matching unrestricted funding from Celgene Pharmaceuticals. The authors gratefully acknowledge the support of Jim Broatch of the RSDA, and the assistance of Heather Cairl and Emily Close MSW, LSW. None of the authors have a conflict of interest as to this work.
PY - 2010/8
Y1 - 2010/8
N2 - Current IASP diagnostic criteria for CRPS have low specificity, potentially leading to overdiagnosis. This validation study compared current IASP diagnostic criteria for CRPS to proposed new diagnostic criteria (the "Budapest Criteria") regarding diagnostic accuracy. Structured evaluations of CRPS-related signs and symptoms were conducted in 113 CRPS-I and 47 non-CRPS neuropathic pain patients. Discriminating between diagnostic groups based on presence of signs or symptoms meeting IASP criteria showed high diagnostic sensitivity (1.00), but poor specificity (0.41), replicating prior work. In comparison, the Budapest clinical criteria retained the exceptional sensitivity of the IASP criteria (0.99), but greatly improved upon the specificity (0.68). As designed, the Budapest research criteria resulted in the highest specificity (0.79), again replicating prior work. Analyses indicated that inclusion of four distinct CRPS components in the Budapest Criteria contributed to enhanced specificity. Overall, results corroborate the validity of the Budapest Criteria and suggest they improve upon existing IASP diagnostic criteria for CRPS.
AB - Current IASP diagnostic criteria for CRPS have low specificity, potentially leading to overdiagnosis. This validation study compared current IASP diagnostic criteria for CRPS to proposed new diagnostic criteria (the "Budapest Criteria") regarding diagnostic accuracy. Structured evaluations of CRPS-related signs and symptoms were conducted in 113 CRPS-I and 47 non-CRPS neuropathic pain patients. Discriminating between diagnostic groups based on presence of signs or symptoms meeting IASP criteria showed high diagnostic sensitivity (1.00), but poor specificity (0.41), replicating prior work. In comparison, the Budapest clinical criteria retained the exceptional sensitivity of the IASP criteria (0.99), but greatly improved upon the specificity (0.68). As designed, the Budapest research criteria resulted in the highest specificity (0.79), again replicating prior work. Analyses indicated that inclusion of four distinct CRPS components in the Budapest Criteria contributed to enhanced specificity. Overall, results corroborate the validity of the Budapest Criteria and suggest they improve upon existing IASP diagnostic criteria for CRPS.
KW - CRPS
KW - Complex Regional Pain Syndrome
KW - Diagnosis
KW - RSD
KW - Reflex sympathetic dystrophy
KW - Validation
UR - http://www.scopus.com/inward/record.url?scp=77955303527&partnerID=8YFLogxK
U2 - 10.1016/j.pain.2010.04.030
DO - 10.1016/j.pain.2010.04.030
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AN - SCOPUS:77955303527
SN - 0304-3959
VL - 150
SP - 268
EP - 274
JO - Pain
JF - Pain
IS - 2
ER -