TY - JOUR
T1 - Vaccinia virus infection suppresses the cell microRNA machinery
AU - Grinberg, Moran
AU - Gilad, Shlomit
AU - Meiri, Eti
AU - Levy, Asaf
AU - Isakov, Ofer
AU - Ronen, Roy
AU - Shomron, Noam
AU - Bentwich, Zvi
AU - Shemer-Avni, Yonat
N1 - Funding Information:
This work was supported by the Israel Science Foundation (grant no. 1375/05) and the Israel Ministry for Science, Culture, and Sport (grant no. 3-4435). The sponsor had no role in the study.
PY - 2012/9
Y1 - 2012/9
N2 - MicroRNAs are key players in the regulation of gene expression by posttranscriptional suppression. They are involved in physiological processes, and thus their deregulation may contribute to the development of diseases and progression of cancer. Virus-encoded microRNAs and microRNAs of host origin play an important role in controlling the virus life cycle and immunity. The aim of this study was to determine the effect of vaccinia virus (VACV) infection on the expression of host-encoded microRNAs. A marked general suppression of most microRNAs in the infected cells was observed within 24 hours after VACV infection of a number of cell types. We demonstrate that this suppression was associated with abrogation of expression of the Dicer1 enzyme, which is a key enzyme in the generation of microRNAs.
AB - MicroRNAs are key players in the regulation of gene expression by posttranscriptional suppression. They are involved in physiological processes, and thus their deregulation may contribute to the development of diseases and progression of cancer. Virus-encoded microRNAs and microRNAs of host origin play an important role in controlling the virus life cycle and immunity. The aim of this study was to determine the effect of vaccinia virus (VACV) infection on the expression of host-encoded microRNAs. A marked general suppression of most microRNAs in the infected cells was observed within 24 hours after VACV infection of a number of cell types. We demonstrate that this suppression was associated with abrogation of expression of the Dicer1 enzyme, which is a key enzyme in the generation of microRNAs.
UR - http://www.scopus.com/inward/record.url?scp=84865778138&partnerID=8YFLogxK
U2 - 10.1007/s00705-012-1366-z
DO - 10.1007/s00705-012-1366-z
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AN - SCOPUS:84865778138
SN - 0304-8608
VL - 157
SP - 1719
EP - 1727
JO - Archives of Virology
JF - Archives of Virology
IS - 9
ER -
