Vaccines to prevent and treat autoimmune diseases

F. Mor*, I. R. Cohen

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review


The current therapy for human autoimmune disease is based on nonselective immunosuppression achieved by corticosteroids or cytotoxic drugs. This form of therapy is toxic and frequently not effective in curing the disease. The study of experimental autoimmune disease models indicates that the pathogenic population of immune cells is restricted in terms of T-cell receptor gene usage and peptide epitopes recognized in the self-antigens. The recent developments in understanding of the pathophysiology of autoimmune disease point to the crucial role of the pathogenic T cell, the autoantigenic peptide, and the major histocompatibility complex molecules as well as the regulatory T-cell population in the disease process. The purpose of this review is to describe the use of vaccines to prevent and treat autoimmune disease. Encouraging results in animal models using vaccines based on the pathogenic T cell or the autoantigen have prompted the design of novel and selective immune-based therapies for human autoimmune disease.

Original languageEnglish
Pages (from-to)345-349
Number of pages5
JournalInternational Archives of Allergy and Immunology
Issue number4
StatePublished - 1995
Externally publishedYes


  • Autoimmune disease vaccines
  • Immunoregulation
  • Peptide therapy
  • T-cell vaccination, oral tolerance


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