Vaccinations and secondary immune thrombocytopenia with antiphospholipid antibodies by human papillomavirus vaccine

Mojca Bizjak; Or Bruck; Darja Kanduc; Sonja Praprotnik; Yehuda Shoenfeld

doi:10.1053/j.seminhematol.2016.04.014

Vaccinations and secondary immune thrombocytopenia with antiphospholipid antibodies by human papillomavirus vaccine

Mojca Bizjak
, Or Bruck
, Darja Kanduc
, Sonja Praprotnik
, Yehuda Shoenfeld^*

^*Corresponding author for this work

Clinical Departments

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

A 13-year-old girl developed immune thrombocytopenic purpura (ITP) and concomitant positive antiphospholipid antibodies (aPL) following vaccination with a quadrivalent human papillomavirus (HPV) vaccine. During the course of a disease, she developed clinical manifestation with bleeding and she was treated with intravenous immunoglobulins. Consequently, the number of her platelets remained critically low and she was put on corticosteroids and rituximab. Since then, her platelet count remain within the normal range, but her aPL are still present.

Original language	English
Article number	50869
Pages (from-to)	S48-S50
Journal	Seminars in Hematology
Volume	53
DOIs	https://doi.org/10.1053/j.seminhematol.2016.04.014
State	Published - 1 Apr 2016

Keywords

ASIA syndrome
Antiphospholipid antibodies
Human papillomavirus
Immune thrombocytopenic purpura
Molecular mimicry
Vaccine

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10.1053/j.seminhematol.2016.04.014

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title = "Vaccinations and secondary immune thrombocytopenia with antiphospholipid antibodies by human papillomavirus vaccine",

abstract = "A 13-year-old girl developed immune thrombocytopenic purpura (ITP) and concomitant positive antiphospholipid antibodies (aPL) following vaccination with a quadrivalent human papillomavirus (HPV) vaccine. During the course of a disease, she developed clinical manifestation with bleeding and she was treated with intravenous immunoglobulins. Consequently, the number of her platelets remained critically low and she was put on corticosteroids and rituximab. Since then, her platelet count remain within the normal range, but her aPL are still present.",

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AU - Bizjak, Mojca

AU - Bruck, Or

AU - Kanduc, Darja

AU - Praprotnik, Sonja

AU - Shoenfeld, Yehuda

PY - 2016/4/1

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N2 - A 13-year-old girl developed immune thrombocytopenic purpura (ITP) and concomitant positive antiphospholipid antibodies (aPL) following vaccination with a quadrivalent human papillomavirus (HPV) vaccine. During the course of a disease, she developed clinical manifestation with bleeding and she was treated with intravenous immunoglobulins. Consequently, the number of her platelets remained critically low and she was put on corticosteroids and rituximab. Since then, her platelet count remain within the normal range, but her aPL are still present.

AB - A 13-year-old girl developed immune thrombocytopenic purpura (ITP) and concomitant positive antiphospholipid antibodies (aPL) following vaccination with a quadrivalent human papillomavirus (HPV) vaccine. During the course of a disease, she developed clinical manifestation with bleeding and she was treated with intravenous immunoglobulins. Consequently, the number of her platelets remained critically low and she was put on corticosteroids and rituximab. Since then, her platelet count remain within the normal range, but her aPL are still present.

KW - ASIA syndrome

KW - Antiphospholipid antibodies

KW - Human papillomavirus

KW - Immune thrombocytopenic purpura

KW - Molecular mimicry

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Vaccinations and secondary immune thrombocytopenia with antiphospholipid antibodies by human papillomavirus vaccine

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Keywords

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