TY - JOUR
T1 - Vaccination for atherosclerosis
AU - De Carvalho, Jozélio Freire
AU - Pereira, Rosa Maria R.
AU - Shoenfeld, Yehuda
N1 - Funding Information:
Carvalho JF received a grant from Federico Foundation. J.F.deCarvalho . R. M. R. Pereira Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo e Hospital das Clinicas da Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil
PY - 2010/4
Y1 - 2010/4
N2 - Atherosclerosis is an inflammatory disease, and several antigens have been shown to activate the immune response and affect the development of atherogenesis. This suggests that modulation of the immune system could represent a useful approach to prevent and/or treat this disorder. A vaccination approach might be a useful, effective tool in the modern arsenal of cardiovascular therapy and could possibly be used on a large scale at a low cost. Several modalities of vaccines have been tested against lipoproteins, cholesterol, molecules involved in cholesterol metabolism, atherosclerosis- associated microorganisms, and other molecules (heat shock protein, CD99, vascular endothelial growth factor-receptor, interleukin-2), with promising results. Nevertheless, a deeper understanding of the role of immunization in atherosclerosis will be essential to the use of vaccines in clinical medicine.
AB - Atherosclerosis is an inflammatory disease, and several antigens have been shown to activate the immune response and affect the development of atherogenesis. This suggests that modulation of the immune system could represent a useful approach to prevent and/or treat this disorder. A vaccination approach might be a useful, effective tool in the modern arsenal of cardiovascular therapy and could possibly be used on a large scale at a low cost. Several modalities of vaccines have been tested against lipoproteins, cholesterol, molecules involved in cholesterol metabolism, atherosclerosis- associated microorganisms, and other molecules (heat shock protein, CD99, vascular endothelial growth factor-receptor, interleukin-2), with promising results. Nevertheless, a deeper understanding of the role of immunization in atherosclerosis will be essential to the use of vaccines in clinical medicine.
KW - Atherosclerosis
KW - Autoimmune diseases
KW - Autoimmunity
KW - Vaccination
UR - http://www.scopus.com/inward/record.url?scp=77952489467&partnerID=8YFLogxK
U2 - 10.1007/s12016-009-8145-y
DO - 10.1007/s12016-009-8145-y
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AN - SCOPUS:77952489467
VL - 38
SP - 135
EP - 140
JO - Clinical Reviews in Allergy and Immunology
JF - Clinical Reviews in Allergy and Immunology
SN - 1080-0549
IS - 2-3
ER -
