Uveitic Glaucoma: Long-term Clinical Outcome and Risk Factors for Progression

Yael Sharon, Ronit Friling, Moshe Luski, Belén Quizhpe Campoverde, Radgonde Amer, Michal Kramer

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To study the long-term clinical outcomes of uveitic glaucoma and to identify risk factors for progression. Methods: Retrospective study of uveitic glaucoma patients in two tertiary medical centers in 2003–2015. Patient- and disease-related data was retrieved. Clinical parameters and visual fields measured at predetermined time points were recorded. Outcome measures included maintaining intraocular pressure ≤21 mmHg and preserving visual fields. Results: Included were 34 patients (53 eyes), with a mean follow-up of 7 years. Idiopathic anterior uveitis and open-angle glaucoma were most common. In total, 62% of eyes were steroid responders. Higher IOP was associated with posterior synechiae, peripheral-anterior synechiae, steroidal, and immunomodulatory therapy (p<0.05). Glaucomatous field defects developed in 49%, with most showing no progression, despite elevation of cup-to-disc ratio (p<0.05). Conclusions: Chronic severe uveitis, expressed by structural complications and immunomodulatory therapy, was associated with high IOP and the need for more IOP lowering medications, but was unrelated to glaucomatous damage.

Original languageEnglish
Pages (from-to)740-747
Number of pages8
JournalOcular Immunology and Inflammation
Volume25
Issue number6
DOIs
StatePublished - 2 Nov 2017

Keywords

  • Clinical outcome
  • risk factors
  • secondary glaucoma
  • uveitis
  • visual field

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