Uveal Melanoma with Extraocular Spread

Andrew W. Stacey, Mahmud Mossa-Basha, Ido Didi Fabian*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Uveal melanoma can invade the sclera and grow into the extrascleral space. When this occurs with anterior uveal tumors, the underlying ciliary body melanoma will create subconjunctival pigmentation in the perilimbal region that can be confused for conjunctival pigmentation. Posterior uveal melanomas that grow through the sclera may present with orbital signs and an orbital mass or they may be seen on routine evaluations of newly diagnosed intraocular melanomas. Imaging characteristics demonstrate a choroidal mass within the globe adjacent to the extrascleral lesion. Melanomas often demonstrate spontaneous hyperintensity on T1 weighted images and routinely show contrast enhancement. Ultrasound can be performed readily in clinic and can often lead to a presumptive diagnosis. Computed tomography and magnetic resonance imaging are important in the diagnosis and surgical planning of larger lesions.

Original languageEnglish
Title of host publicationAtlas of Orbital Imaging
PublisherSpringer International Publishing
Number of pages6
ISBN (Electronic)9783030624262
ISBN (Print)9783030624255
StatePublished - 1 Jan 2021


  • Exophytic
  • Extrascleral
  • Orbital melanoma
  • Uveal melanoma


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