Uterine rupture during pregnancy: The URIDA (uterine rupture international data acquisition) study

Andrea Tinelli*, Ioannis P. Kosmas, Jose "Tony" Carugno, Howard Carp, Antonio Malvasi, Shlomo B. Cohen, Antonio Simone Laganà, Marta Angelini, Paolo Casadio, Jenifer Chayo, Ettore Cicinelli, Sandro Gerli, Josè Palacios Jaraquemada, Giulia Magnarelli, Mykhailo V. Medvediev, Josè Metello, Luigi Nappi, Jude Okohue, Radmila Sparic, Radomir StefanovićAvinoam Tzabari, Antonella Vimercati

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Objective: To describe the characteristics and peripartum outcomes of patients diagnosed with uterine rupture (UR) by an observational cohort retrospective study on 270 patients. Methods: Demographic information, surgical history, symptoms, and postoperative outcome of women and neonates after UR were collected in a large database. The statistical analysis searched for correlation between UR, previous uterine interventions, fibroids, and the successive perinatal outcomes in women with previous UR. Results: Uterine rupture was significantly associated with previous uterine surgery, occurring, on average, at 36 weeks of pregnancy in women also without previous uterine surgery. UR did not rise exponentially with an increasing number of uterine operations. Fibroids were related to UR. The earliest UR occurred at 159 days after hysteroscopic myomectomy, followed by laparoscopic myomectomy (251 days) and laparotomic myomectomy (253 days). Fertility preservation was feasible in several women. Gestational age and birth weight seemed not to be affected in the subsequent pregnancy. Conclusion: Data analysis showed that previous laparoscopic and abdominal myomectomies were associated with UR in pregnancy, and hysteroscopic myomectomy was associated at earlier gestational ages. UR did not increase exponentially with an increasing number of previous scars. UR should not be considered a contraindication to future pregnancies.

Original languageEnglish
Pages (from-to)76-84
Number of pages9
JournalInternational Journal of Gynecology and Obstetrics
Issue number1
StatePublished - Apr 2022
Externally publishedYes


  • cesarean sections
  • labor management
  • myomectomy
  • pregnancy
  • related complications
  • uterine rupture


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