TY - JOUR
T1 - Uterine preparation with estrogen for oocyte donation
T2 - Assessing the effect of treatment duration on pregnancy rates
AU - Yaron, Y.
AU - Amit, A.
AU - Mani, A.
AU - Yovel, I.
AU - Kogosowski, A.
AU - Peyser, M. R.
AU - David, M. P.
AU - Lessing, J. B.
PY - 1995
Y1 - 1995
N2 - Objective: To assess the effect of the duration of uterine preparation with E2 on pregnancy rates (PRs) in oocyte donation. Design: A retrospective study. Setting: IVF-ET Unit, oocyte donation program. Patients: Pour hundred eleven patients undergoing 865 ET cycles after oocyte donation. Uterine preparation consisted of 6 mg/d E2 valerate. The duration of treatment varied according to the availability of the oocytes for donation. Progesterone, 100 mg/d, was added upon oocyte retrieval. Patients were divided into seven groups according to the duration of uterine preparation with E2, in 5-day ranks. Main Outcome Measures: Pregnancy rates per ET according to the duration of uterine preparation. Results: No differences were noted in the mean age, number of oocytes received, fertilization rates, or number of embryos transferred when comparing all groups. Pregnancy rates ranged from 19% to 27% for E2 treatment of 5 to 35 days. Conclusion: Endometrial preparation in anonymous oocyte donation programs is achieved with continuous administration of E2 until oocytes become available. Our results show that this treatment may be extended for as long as 5 weeks with no significant decrease in PRs.
AB - Objective: To assess the effect of the duration of uterine preparation with E2 on pregnancy rates (PRs) in oocyte donation. Design: A retrospective study. Setting: IVF-ET Unit, oocyte donation program. Patients: Pour hundred eleven patients undergoing 865 ET cycles after oocyte donation. Uterine preparation consisted of 6 mg/d E2 valerate. The duration of treatment varied according to the availability of the oocytes for donation. Progesterone, 100 mg/d, was added upon oocyte retrieval. Patients were divided into seven groups according to the duration of uterine preparation with E2, in 5-day ranks. Main Outcome Measures: Pregnancy rates per ET according to the duration of uterine preparation. Results: No differences were noted in the mean age, number of oocytes received, fertilization rates, or number of embryos transferred when comparing all groups. Pregnancy rates ranged from 19% to 27% for E2 treatment of 5 to 35 days. Conclusion: Endometrial preparation in anonymous oocyte donation programs is achieved with continuous administration of E2 until oocytes become available. Our results show that this treatment may be extended for as long as 5 weeks with no significant decrease in PRs.
KW - IVF
KW - endometrial receptivity
KW - estrogen
KW - oocyte donation
UR - http://www.scopus.com/inward/record.url?scp=0029043039&partnerID=8YFLogxK
U2 - 10.1016/S0015-0282(16)57612-2
DO - 10.1016/S0015-0282(16)57612-2
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AN - SCOPUS:0029043039
SN - 0015-0282
VL - 63
SP - 1284
EP - 1286
JO - Fertility and Sterility
JF - Fertility and Sterility
IS - 6
ER -