Usefulness of anti-oxidized LDL antibody determination for assessment of clinical control in patients with heart failure

Jacob George, Dov Wexler, Arie Roth, Tomer Barak, David Sheps, Gad Keren

Research output: Contribution to journalArticlepeer-review

Abstract

Background: It has been suggested that oxidative stress may play a role in the pathogenesis of heart failure, this may have potential implications for therapeutic strategies. However, measures of oxidative stress are subject to confounding inaccuracies. IgG antibodies to oxidized LDL reflect exposure to the lipoprotein over an extended period and may thus mirror oxidative stress over a prolonged time frame. Therefore, we tested the hypothesis that anti-oxLDL antibodies correlate with the control of heart failure (HF), as manifested by hospital admissions for cardiac dysfunction. Methods: One hundred and two consecutive patients attending the HF clinic with either systolic or diastolic HF were enrolled and the quality of clinical control was evaluated by assessing hospital admissions over the year prior to index determination of the oxidative stress marker. Antibodies to oxLDL were determined by ELISA and pro-BNP levels were also measured. Results: Most patients (mean age 71.5 years) had systolic HF; mean NYHA functional class was 2.7 and mean left ventricular ejection fraction was 39.7%. Anti-oxLDL antibodies, but not pro-BNP, correlated significantly with mean NYHA score (averaged from all clinic visits in the year prior to blood testing), and with hospital admissions over the year prior to blood testing. Mean IgG anti-oxLDL antibody levels in patients with hospital admissions were 3.4 times higher than those in subjects not hospitalized over the previous year. Conclusion: IgG anti-oxLDL antibody levels correlate with the severity of HF.

Original languageEnglish
Pages (from-to)58-62
Number of pages5
JournalEuropean Journal of Heart Failure
Volume8
Issue number1
DOIs
StatePublished - Jan 2006

Keywords

  • Antibodies
  • Heart failure
  • Oxidative stress
  • Oxidized-LDL
  • Pro-BNP

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