Use of mitomycin C for treatment of keloid: A preliminary report

Yoav P. Talmi*, Arie Orenstein, Michael Wolf, Jona Kronenberg

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


OBJECTIVES: Mitomycin C (MC) is an anti-neoplastic agent with an anti-proliferative effect on fibroblasts. We set out to evaluate the effect of MC application following keloid excision. STUDY DESIGN AND SETTING: Patients with keloid in a tertiary referral center were enrolled in a prospective study. The scar was excised and prior to skin closure, a pledget with 1 cc of MC 0.4 mg/mL was applied for 5 minutes. Patient satisfaction and keloid thickness were assessed. RESULTS: All patients were satisfied with the results, although complete disappearance of the keloid was evident only in two. Keloid thickness was measured and ranged from 5 to 26 mm. Following surgery and treatment at 2 months thickness ranged from 0 to 8 mm. CONCLUSIONS: MC application following scar resection appears to be effective in treatment of keloid. SIGNIFICANCE: As no specific effective treatment for keloid is currently available, utilization of this readily available therapeutic agent may improve treatment outcome.

Original languageEnglish
Pages (from-to)598-601
Number of pages4
JournalOtolaryngology - Head and Neck Surgery
Issue number4
StatePublished - Apr 2005


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