Use of dynamic light scattering for assessing acute pain

Suzanne Broens, Adi Schejter Bar-Noam, Ilya Fine, Louis Shenkman, Monique Van Velzen, Marieke Niesters, Albert Dahan

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review


Currently there is no accurate objective measure for monitoring pain during the state of drug-induced unconsciousness (such as during surgical anesthesia). Moreover, the absence of an objective measure for detecting pain hampers the physician's ability to provide an optimal dose of analgesics. We have developed a novel method for detecting pain by quantifying skin blood flow dynamics using a miniaturized dynamic light scattering (mDLS) sensor placed on the skin. Healthy awake volunteers were studied with mDLS sensors placed on both index fingers while being subjected to a series of cutaneous painful stimuli (electric shock and heat), randomly applied in a range between the subjects' pain threshold and tolerance. Power spectrum analysis of the recorded signal was performed with a focus on two frequency bands, representing relative blood flow of non-pulsatile vessels and larger pulsatile arterioles. Relative blood flow of pulsatile vessels decreased while flow of non-pulsatile vessels increased in response to painful stimulation, with a high correlation between the responses obtained on the right and left index fingers. The changes in hemodynamics that occur during painful stimulation suggest a redistribution of blood flow between pulsatile and non-pulsatile vessels, probably related to central activation of the sympathetic system combined with local dynamic autoregulatory responses. Thus, optical parameters of skin blood flow can detect nociceptive stimuli and consequently can serve as objective biomarkers of pain.

Original languageEnglish
Title of host publicationNovel Biophotonics Techniques and Applications V
EditorsArjen Amelink, Seemantini K. Nadkarni
ISBN (Electronic)9781510628434
StatePublished - 2019
EventNovel Biophotonics Techniques and Applications V 2019 - Munich, Germany
Duration: 26 Jun 201927 Jun 2019

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceNovel Biophotonics Techniques and Applications V 2019


  • anesthesia
  • blood flow
  • dynamic light scattering
  • laser Doppler
  • nociception
  • pain
  • peripheral vessels


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