Use of Biosimilars in Pediatric Inflammatory Bowel Disease: An Updated Position Statement of the Pediatric IBD Porto Group of ESPGHAN

Lissy De Ridder; Amit Assa; Jiri Bronsky; Claudio Romano; Richard K. Russell; Nadeem A. Afzal; Almuthe C. Hauer; Daniela Knafelz; Paolo Lionetti; Caterina Strisciuglio; Gábor Veres; Harland Winter; Victorien M. Wolters; Malgorzata Sladek; Arnold G. Vulto; Jorge A. Dias

doi:10.1097/MPG.0000000000002141

Use of Biosimilars in Pediatric Inflammatory Bowel Disease: An Updated Position Statement of the Pediatric IBD Porto Group of ESPGHAN

Lissy De Ridder^*, Amit Assa, Jiri Bronsky, Claudio Romano, Richard K. Russell, Nadeem A. Afzal, Almuthe C. Hauer, Daniela Knafelz, Paolo Lionetti, Caterina Strisciuglio, Gábor Veres, Harland Winter, Victorien M. Wolters, Malgorzata Sladek, Arnold G. Vulto, Jorge A. Dias

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

TBiologic therapies have changed the outcome of both adult and pediatric patients with Inflammatory Bowel Disease (IBD). In September 2013, the first biosimilar of infliximab was introduced into the pharmaceutical market. In 2015, a first position paper on the use of biosimilars in pediatric IBD was published by the ESPGHAN IBD Porto group. Since then, more data have accumulated for both adults and children demonstrating biosimilars are an effective and safe alternative to the originator. In this updated position statement, we summarize current evidence and provide joint consensus statements regarding the recommended practice of biosimilar use in children with IBD.

Original language	English
Pages (from-to)	144-153
Number of pages	10
Journal	Journal of Pediatric Gastroenterology and Nutrition
Volume	68
Issue number	1
DOIs	https://doi.org/10.1097/MPG.0000000000002141
State	Published - 2019

Keywords

Crohn disease
biologics
biologics
biosimilars
biosimilars
inflammatory bowel disease
pediatric
ulcerative colitis

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10.1097/MPG.0000000000002141

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De Ridder, L., Assa, A., Bronsky, J., Romano, C., Russell, R. K., Afzal, N. A., Hauer, A. C., Knafelz, D., Lionetti, P., Strisciuglio, C., Veres, G., Winter, H., Wolters, V. M., Sladek, M., Vulto, A. G., & Dias, J. A. (2019). Use of Biosimilars in Pediatric Inflammatory Bowel Disease: An Updated Position Statement of the Pediatric IBD Porto Group of ESPGHAN. Journal of Pediatric Gastroenterology and Nutrition, 68(1), 144-153. https://doi.org/10.1097/MPG.0000000000002141

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abstract = "TBiologic therapies have changed the outcome of both adult and pediatric patients with Inflammatory Bowel Disease (IBD). In September 2013, the first biosimilar of infliximab was introduced into the pharmaceutical market. In 2015, a first position paper on the use of biosimilars in pediatric IBD was published by the ESPGHAN IBD Porto group. Since then, more data have accumulated for both adults and children demonstrating biosimilars are an effective and safe alternative to the originator. In this updated position statement, we summarize current evidence and provide joint consensus statements regarding the recommended practice of biosimilar use in children with IBD.",

keywords = "Crohn disease, biologics, biologics, biosimilars, biosimilars, inflammatory bowel disease, pediatric, ulcerative colitis",

author = "{De Ridder}, Lissy and Amit Assa and Jiri Bronsky and Claudio Romano and Russell, {Richard K.} and Afzal, {Nadeem A.} and Hauer, {Almuthe C.} and Daniela Knafelz and Paolo Lionetti and Caterina Strisciuglio and G{\'a}bor Veres and Harland Winter and Wolters, {Victorien M.} and Malgorzata Sladek and Vulto, {Arnold G.} and Dias, {Jorge A.}",

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year = "2019",

doi = "10.1097/MPG.0000000000002141",

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De Ridder, L, Assa, A, Bronsky, J, Romano, C, Russell, RK, Afzal, NA, Hauer, AC, Knafelz, D, Lionetti, P, Strisciuglio, C, Veres, G, Winter, H, Wolters, VM, Sladek, M, Vulto, AG & Dias, JA 2019, 'Use of Biosimilars in Pediatric Inflammatory Bowel Disease: An Updated Position Statement of the Pediatric IBD Porto Group of ESPGHAN', Journal of Pediatric Gastroenterology and Nutrition, vol. 68, no. 1, pp. 144-153. https://doi.org/10.1097/MPG.0000000000002141

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AU - De Ridder, Lissy

AU - Assa, Amit

AU - Bronsky, Jiri

AU - Romano, Claudio

AU - Russell, Richard K.

AU - Afzal, Nadeem A.

AU - Hauer, Almuthe C.

AU - Knafelz, Daniela

AU - Lionetti, Paolo

AU - Strisciuglio, Caterina

AU - Veres, Gábor

AU - Winter, Harland

AU - Wolters, Victorien M.

AU - Sladek, Malgorzata

AU - Vulto, Arnold G.

AU - Dias, Jorge A.

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PY - 2019

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AB - TBiologic therapies have changed the outcome of both adult and pediatric patients with Inflammatory Bowel Disease (IBD). In September 2013, the first biosimilar of infliximab was introduced into the pharmaceutical market. In 2015, a first position paper on the use of biosimilars in pediatric IBD was published by the ESPGHAN IBD Porto group. Since then, more data have accumulated for both adults and children demonstrating biosimilars are an effective and safe alternative to the originator. In this updated position statement, we summarize current evidence and provide joint consensus statements regarding the recommended practice of biosimilar use in children with IBD.

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KW - biologics

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Use of Biosimilars in Pediatric Inflammatory Bowel Disease: An Updated Position Statement of the Pediatric IBD Porto Group of ESPGHAN

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