Use of applied biosystems 7900HT sequence detection system and taqman assay for detection of quinolone-resistant Neisseria gonorrhoeae

Julie Giles; Justin Hardick; Jeffrey Yuenger; Michael Dan; Karl Reich; Jonathan Zenilman

doi:10.1128/JCM.42.7.3281-3283.2004

Use of applied biosystems 7900HT sequence detection system and taqman assay for detection of quinolone-resistant Neisseria gonorrhoeae

Julie Giles^*, Justin Hardick, Jeffrey Yuenger, Michael Dan, Karl Reich, Jonathan Zenilman

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Mutations in quinolone resistance-determining regions (QRDRs) have been associated with quinolone-resistant Neisseria gonorrhoeae (QRNG). Since diagnostic nucleic acid amplification tests for gonococci are now in frequent use, molecular detection of QRNG could facilitate surveillance in the absence of culture. Here we describe a real-time molecular assay for detecting QRDR mutations in gonococci.

Original language	English
Pages (from-to)	3281-3283
Number of pages	3
Journal	Journal of Clinical Microbiology
Volume	42
Issue number	7
DOIs	https://doi.org/10.1128/JCM.42.7.3281-3283.2004
State	Published - Jul 2004
Externally published	Yes

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10.1128/JCM.42.7.3281-3283.2004

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abstract = "Mutations in quinolone resistance-determining regions (QRDRs) have been associated with quinolone-resistant Neisseria gonorrhoeae (QRNG). Since diagnostic nucleic acid amplification tests for gonococci are now in frequent use, molecular detection of QRNG could facilitate surveillance in the absence of culture. Here we describe a real-time molecular assay for detecting QRDR mutations in gonococci.",

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AU - Dan, Michael

AU - Reich, Karl

AU - Zenilman, Jonathan

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AB - Mutations in quinolone resistance-determining regions (QRDRs) have been associated with quinolone-resistant Neisseria gonorrhoeae (QRNG). Since diagnostic nucleic acid amplification tests for gonococci are now in frequent use, molecular detection of QRNG could facilitate surveillance in the absence of culture. Here we describe a real-time molecular assay for detecting QRDR mutations in gonococci.

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Use of applied biosystems 7900HT sequence detection system and taqman assay for detection of quinolone-resistant Neisseria gonorrhoeae

Abstract

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