USAGE DU RADIOCUIVRE ET DU RADIOZINE POUR LE DIAGNOSTIC PSYCHIATRIQUE

Translated title of the contribution: The use of radioactive copper and zinc in psychiatric diagnosis

P. Czerniak, S. T. Zwas

Research output: Contribution to journalArticlepeer-review

Abstract

Three conclusions may be drawn from the results supplemented by some known data. Administration of the phenothiazines results in rise of the amount of 65Zn taken up by certain limbic structures of the brain. Cassano found a high concentration of 35S labelled chlorpromazine in the rat hippocampus and Ashby an increase in carbonic anhydrase in the brains of rats thus treated and fall of this enzyme in the brain of untreated schizophrenics. There thus probably exists a cause and effect relation between, on the one hand, the changes in the level of Zn and carbonic anhydrase in the encephalon (mesencephalon) in schizophrenics and, on the other, the influence of the phenothiazines on the distribution of encephalic zinc. Will it then be possible to claim that a lack of a zinc compound produces the mental illness and that the phenothiazines have favorable effect by raising the zinc level?

Translated title of the contributionThe use of radioactive copper and zinc in psychiatric diagnosis
Original languageFrench
Pages (from-to)I/4
JournalAnnales Medico-Psychologiques
Volume134
StatePublished - 1976
Externally publishedYes

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