Urine leukotriene B4 in familial Mediterranean fever

Ariel G. Bentancur, Nava Naveh, Jonathan Lancri, Ben Ami Selah, Avi Livneh*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Objective. To determine urinary leukotriene B4 (LTB4) levels and their role in FMF. Methods. Urinary LTB4 levels were studied using a commercial ELISA kit in 12 FMF patients during abdominal attacks, and 20 FMF patients during remission. Results. Urinary LTB4 levels in FMF patients during attacks were comparable to those during remission, but higher than normal levels (p = 0.03). Conclusions. These findings suggest a persistent activation of the leukotriene pathway in FMF. Whether elevated LTB4 levels are the cause or the effect of inflammation is yet to be determined.

Original languageEnglish
Pages (from-to)S56-S58
JournalClinical and Experimental Rheumatology
Volume22
Issue number4 SUPPL. 24
StatePublished - 2004

Keywords

  • Arachidonic acid
  • Cytochrome P450
  • FMF
  • Inflammation
  • Leukotriene B4
  • Lipoxygenase
  • Pyrin

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