Urinary prostaglandins E2 and F(2α) in chronic renal failure. Influence of chronic and acute changes in Na Balance

M. Schneider, M. Rathaus, J. Shapira, J. Bernheim

Research output: Contribution to journalArticlepeer-review

Abstract

The role played by renal prostaglandins E2 (PGE2) and F(2α) (PGF(2α) in the modification of sodium homeostasis in chronic renal failure (CFR) was studied. The 24-hour urinary excretion of PGE2 and PGF(2α) was measured before and after 5 days of a diet containing less than 20 mmol/day of sodium in 6 patients with CRF. At the end of this period, an acute sodium load (77 mmol/h of NaCl for 4 H) was administered and prostaglandins measured in hourly urine collections. In contrast to the findings previously reported in normal subjects, PGE2, and PGF(2α) decreased with the low-sodium diet. The ratio PGE2/PGF(2α) (reflecting the activity of the enzyme PGE2-9-ketoreductase) was greatly increased and did not change with the low-sodium diet. The acute sodium load induced an increase in urinary prostaglandins. The results suggest that prostaglandins may contribute to natriuresis in CRF, under basal conditions, after a short-term sodium depletion and in response to an acute sodium load. The changes in prostaglandin excretion in CRF could be related to decreased activity of PGE2-9-ketoreductase.

Original languageEnglish
Pages (from-to)152-154
Number of pages3
JournalNephron
Volume40
Issue number2
StatePublished - 1985
Externally publishedYes

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