Urinary concentrations of phthalate metabolites, bisphenols and personal care product chemical biomarkers in pregnant women in Israel

Ronit Machtinger*, Tamar Berman, Michal Adir, Abdallah Mansur, Andrea A. Baccarelli, Catherine Racowsky, Antonia M. Calafat, Russ Hauser, Ravit Nahum

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Mounting evidence suggests possible adverse effects of intrauterine exposure to certain phenols and phthalates, two classes of endocrine disruptor chemicals, on the developing fetus, with consequences into later life. These findings have contributed to the replacement of some chemicals, such as di‑2‑ethylhexyl phthalate (DEHP) and bisphenol A (BPA), in consumer products. For the current study we quantified urinary concentrations of biomarkers of exposure among 50 pregnant women in Israel to several phthalates, bisphenols and personal care product chemicals, as well as DEHP and BPA alternatives. We detected 14 of the 31 biomarkers in more than 90% of the women. We detected biomarkers of 1,2‑cyclohexane dicarboxylic acid, diisononyl ester (DINCH), bisphenol S, and bisphenol F not as frequently (27-56%). This study is the first to evaluate exposure to triclosan, bisphenols, parabens, and phthalates and BPA alternatives among Israeli pregnant women.

Original languageEnglish
Pages (from-to)319-325
Number of pages7
JournalEnvironment international
Volume116
DOIs
StatePublished - Jul 2018

Funding

FundersFunder number
National Institutes of HealthR01ES021357
National Institute of Environmental Health SciencesR21ES024236
Environment and Health Fund1502

    Keywords

    • Alternatives
    • Bisphenols
    • Personal care product chemicals
    • Phthalates
    • Pregnancy

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