Ureteroscopic biopsy of upper tract urothelial carcinoma: Comparison of basket and forceps

Nir Kleinmann, Kelly A. Healy, Scott G. Hubosky, David Margel, Marluce Bibbo, Demetrius H. Bagley*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To compare two different biopsy devices for upper tract urothelial carcinoma (UTUC) and evaluate the pathologic result obtained by these devices. Patients and Methods: From January 2008 to December 2010, 414 ureteroscopies were performed and 504 biopsies were taken for evaluation of UTUC. Two biopsy devices were compared: 2.4F stainless steel flat wire basket and 3F cup biopsy forceps. The effect of the biopsy device on obtaining an adequate pathologic specimen was evaluated using univariate and multivariate binary logistic regression analysis. We also investigated whether tumor grade determination was affected by the biopsy device among patients with a diagnostic biopsy. Results: Diagnosis was successful in 63% and 94% in the forceps and basket groups, respectively (P<0.0001). Among biopsies with a definite diagnosis of UTUC, specific grade was determined in 80% and 93% in the forceps and basket groups, respectively (P=0.033). In subgroup analysis of tumors larger than 10 mm in diameter, diagnosis was obtained in 80% and 94% in the forceps and basket groups, respectively (P=0.037). Cytologic evaluation was found to increase diagnostic rates. Conclusions: The stainless steel flat wire basket was shown to be superior to the 3F cup biopsy forceps in terms of obtaining tissue diagnosis and providing specific grade.

Original languageEnglish
Pages (from-to)1450-1454
Number of pages5
JournalJournal of Endourology
Volume27
Issue number12
DOIs
StatePublished - 1 Dec 2013
Externally publishedYes

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