@article{7972847fb09d44609508f2dfb00fa5cb,
title = "Upregulation of imipramine binding and serotonin uptake by estradiol in female rat brain",
abstract = "This report describes the effect of chronic estradiol treatment on the serotonin transporter in the female rat brain. Both [3H]imipramine binding and [3H]serotonin uptake increased by 20-30% in the frontal cortex and hypothalamus of ovariectomized rats after 12 days of 17β-estradiol treatment. No differences were observed in the binding and uptake parameters as a function of the rats' estrous cycle or in untreated ovariectomized rats, as compared to controls. Estradiol in vitro, inhibits [3H]imipramine binding as well as serotonin uptake in rat brain and human platelets. Like serotonin, estradiol decreases the dissociation rate in vitro of [3H]imipramine from its binding site in a dose-dependent manner.",
keywords = "Estradiol, Gonadal hormone, Imipramine binding, Platelet, Serotonin uptake, Tricyclic antidepressant",
author = "Moshe Rehavi and Hagit Sepcuti and Abraham Weizman",
note = "Funding Information: This research was supported by grants from the Schreiber Foundation, from the United States-Israel BSF (Grant 84-00361) and from the Israel Institute for Psychobiology, Charles E. Smith Family Foundation (Grant 6-86-7) to M.R.",
year = "1987",
month = apr,
day = "28",
doi = "10.1016/S0006-8993(87)80034-3",
language = "אנגלית",
volume = "410",
pages = "135--139",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier B.V.",
number = "1",
}