Upregulation of imipramine binding and serotonin uptake by estradiol in female rat brain

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Abstract

This report describes the effect of chronic estradiol treatment on the serotonin transporter in the female rat brain. Both [3H]imipramine binding and [3H]serotonin uptake increased by 20-30% in the frontal cortex and hypothalamus of ovariectomized rats after 12 days of 17β-estradiol treatment. No differences were observed in the binding and uptake parameters as a function of the rats' estrous cycle or in untreated ovariectomized rats, as compared to controls. Estradiol in vitro, inhibits [3H]imipramine binding as well as serotonin uptake in rat brain and human platelets. Like serotonin, estradiol decreases the dissociation rate in vitro of [3H]imipramine from its binding site in a dose-dependent manner.

Original languageEnglish
Pages (from-to)135-139
Number of pages5
JournalBrain Research
Volume410
Issue number1
DOIs
StatePublished - 28 Apr 1987

Keywords

  • Estradiol
  • Gonadal hormone
  • Imipramine binding
  • Platelet
  • Serotonin uptake
  • Tricyclic antidepressant

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