Upregulation of imipramine binding and serotonin uptake by estradiol in female rat brain

Moshe Rehavi; Hagit Sepcuti; Abraham Weizman

doi:10.1016/S0006-8993(87)80034-3

Upregulation of imipramine binding and serotonin uptake by estradiol in female rat brain

Moshe Rehavi, Hagit Sepcuti, Abraham Weizman

Research output: Contribution to journal › Article › peer-review

Abstract

This report describes the effect of chronic estradiol treatment on the serotonin transporter in the female rat brain. Both [³H]imipramine binding and [³H]serotonin uptake increased by 20-30% in the frontal cortex and hypothalamus of ovariectomized rats after 12 days of 17β-estradiol treatment. No differences were observed in the binding and uptake parameters as a function of the rats' estrous cycle or in untreated ovariectomized rats, as compared to controls. Estradiol in vitro, inhibits [³H]imipramine binding as well as serotonin uptake in rat brain and human platelets. Like serotonin, estradiol decreases the dissociation rate in vitro of [³H]imipramine from its binding site in a dose-dependent manner.

Original language	English
Pages (from-to)	135-139
Number of pages	5
Journal	Brain Research
Volume	410
Issue number	1
DOIs	https://doi.org/10.1016/S0006-8993(87)80034-3
State	Published - 28 Apr 1987

Keywords

Estradiol
Gonadal hormone
Imipramine binding
Platelet
Serotonin uptake
Tricyclic antidepressant

Access to Document

10.1016/S0006-8993(87)80034-3

Cite this

@article{7972847fb09d44609508f2dfb00fa5cb,

title = "Upregulation of imipramine binding and serotonin uptake by estradiol in female rat brain",

abstract = "This report describes the effect of chronic estradiol treatment on the serotonin transporter in the female rat brain. Both [3H]imipramine binding and [3H]serotonin uptake increased by 20-30% in the frontal cortex and hypothalamus of ovariectomized rats after 12 days of 17β-estradiol treatment. No differences were observed in the binding and uptake parameters as a function of the rats' estrous cycle or in untreated ovariectomized rats, as compared to controls. Estradiol in vitro, inhibits [3H]imipramine binding as well as serotonin uptake in rat brain and human platelets. Like serotonin, estradiol decreases the dissociation rate in vitro of [3H]imipramine from its binding site in a dose-dependent manner.",

keywords = "Estradiol, Gonadal hormone, Imipramine binding, Platelet, Serotonin uptake, Tricyclic antidepressant",

author = "Moshe Rehavi and Hagit Sepcuti and Abraham Weizman",

note = "Funding Information: This research was supported by grants from the Schreiber Foundation, from the United States-Israel BSF (Grant 84-00361) and from the Israel Institute for Psychobiology, Charles E. Smith Family Foundation (Grant 6-86-7) to M.R.",

year = "1987",

month = apr,

day = "28",

doi = "10.1016/S0006-8993(87)80034-3",

language = "אנגלית",

volume = "410",

pages = "135--139",

journal = "Brain Research",

issn = "0006-8993",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - Upregulation of imipramine binding and serotonin uptake by estradiol in female rat brain

AU - Rehavi, Moshe

AU - Sepcuti, Hagit

AU - Weizman, Abraham

N1 - Funding Information: This research was supported by grants from the Schreiber Foundation, from the United States-Israel BSF (Grant 84-00361) and from the Israel Institute for Psychobiology, Charles E. Smith Family Foundation (Grant 6-86-7) to M.R.

PY - 1987/4/28

Y1 - 1987/4/28

N2 - This report describes the effect of chronic estradiol treatment on the serotonin transporter in the female rat brain. Both [3H]imipramine binding and [3H]serotonin uptake increased by 20-30% in the frontal cortex and hypothalamus of ovariectomized rats after 12 days of 17β-estradiol treatment. No differences were observed in the binding and uptake parameters as a function of the rats' estrous cycle or in untreated ovariectomized rats, as compared to controls. Estradiol in vitro, inhibits [3H]imipramine binding as well as serotonin uptake in rat brain and human platelets. Like serotonin, estradiol decreases the dissociation rate in vitro of [3H]imipramine from its binding site in a dose-dependent manner.

AB - This report describes the effect of chronic estradiol treatment on the serotonin transporter in the female rat brain. Both [3H]imipramine binding and [3H]serotonin uptake increased by 20-30% in the frontal cortex and hypothalamus of ovariectomized rats after 12 days of 17β-estradiol treatment. No differences were observed in the binding and uptake parameters as a function of the rats' estrous cycle or in untreated ovariectomized rats, as compared to controls. Estradiol in vitro, inhibits [3H]imipramine binding as well as serotonin uptake in rat brain and human platelets. Like serotonin, estradiol decreases the dissociation rate in vitro of [3H]imipramine from its binding site in a dose-dependent manner.

KW - Estradiol

KW - Gonadal hormone

KW - Imipramine binding

KW - Platelet

KW - Serotonin uptake

KW - Tricyclic antidepressant

UR - http://www.scopus.com/inward/record.url?scp=0023256483&partnerID=8YFLogxK

U2 - 10.1016/S0006-8993(87)80034-3

DO - 10.1016/S0006-8993(87)80034-3

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

AN - SCOPUS:0023256483

VL - 410

SP - 135

EP - 139

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 1

ER -

Upregulation of imipramine binding and serotonin uptake by estradiol in female rat brain

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this