TY - JOUR
T1 - Update on progressive multifocal leukoencephalopathy
AU - Steiner, Israel
AU - Berger, Joseph R.
PY - 2012/12
Y1 - 2012/12
N2 - Progressive multifocal leukoencephalopathy (PML) is a severe, often fatal, opportunistic viral infection of the central nervous system that is mainly seen in the context of AIDS and certain monoclonal immune-suppressive therapies. The causative agent, a polyoma virus, named JC virus infects only humans and there is no animal model for PML. This update focuses on information gathered in recent years on the pathogenesis of the disorder, on several clinical aspects associated with diagnosis and therapy, and on the immune reconstitution inflammatory syndrome (IRIS), a complication associated with removal of immunosuppressive therapy in PML.
AB - Progressive multifocal leukoencephalopathy (PML) is a severe, often fatal, opportunistic viral infection of the central nervous system that is mainly seen in the context of AIDS and certain monoclonal immune-suppressive therapies. The causative agent, a polyoma virus, named JC virus infects only humans and there is no animal model for PML. This update focuses on information gathered in recent years on the pathogenesis of the disorder, on several clinical aspects associated with diagnosis and therapy, and on the immune reconstitution inflammatory syndrome (IRIS), a complication associated with removal of immunosuppressive therapy in PML.
KW - Efalizumab
KW - JC virus
KW - Monoclonal antibodies
KW - Natalizumab
KW - Progressive multifocal leukoencephalopathy
KW - Rituximab
UR - http://www.scopus.com/inward/record.url?scp=84870528087&partnerID=8YFLogxK
U2 - 10.1007/s11910-012-0313-4
DO - 10.1007/s11910-012-0313-4
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C2 - 22991070
AN - SCOPUS:84870528087
VL - 12
SP - 680
EP - 686
JO - Current Neurology and Neuroscience Reports
JF - Current Neurology and Neuroscience Reports
SN - 1528-4042
IS - 6
ER -
