TY - JOUR
T1 - Update on gene and immune based therapy for urologic malignancy
AU - Wieder, J.
AU - Freedland, S. J.
AU - Pantuck, A. J.
AU - Zisman, A.
AU - Belldegrun, A. S.
AU - Belldegrun, Arie S.
PY - 2001
Y1 - 2001
N2 - The discovery of genes involved in malignant transformation and tumor growth has lead to the development of anti-cancer gene therapies. In addition, new modifications to immune based therapy have recently been developed. In this review, we focus on modern genetic and immunologic approaches to the treatment of urologic malignancy. We summarize new developments in vectors, tumor suppressors, suicide genes, gene based immunotherapy, tumor vaccines, dendritic cell therapy, and graft vs. tumor therapy. Additional topics described include prostate antigens and prostate specific promoters. Pre-clinical and clinical trials that utilize these therapies are summarized.
AB - The discovery of genes involved in malignant transformation and tumor growth has lead to the development of anti-cancer gene therapies. In addition, new modifications to immune based therapy have recently been developed. In this review, we focus on modern genetic and immunologic approaches to the treatment of urologic malignancy. We summarize new developments in vectors, tumor suppressors, suicide genes, gene based immunotherapy, tumor vaccines, dendritic cell therapy, and graft vs. tumor therapy. Additional topics described include prostate antigens and prostate specific promoters. Pre-clinical and clinical trials that utilize these therapies are summarized.
UR - http://www.scopus.com/inward/record.url?scp=0035170698&partnerID=8YFLogxK
U2 - 10.1016/S1078-1439(01)00127-2
DO - 10.1016/S1078-1439(01)00127-2
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AN - SCOPUS:0035170698
SN - 1078-1439
VL - 6
SP - 265
EP - 275
JO - Urologic Oncology: Seminars and Original Investigations
JF - Urologic Oncology: Seminars and Original Investigations
IS - 6
ER -
