Update on colchicine and its mechanism of action.

Yair Molad

doi:10.1007/s11926-002-0073-2

Update on colchicine and its mechanism of action.

Yair Molad^*

^*Corresponding author for this work

Rabin Medical Center Israel

Research output: Contribution to journal › Review article › peer-review

195 Scopus citations

Abstract

Colchicine is a unique anti-inflammatory drug with respect to its limited clinical usefulness and its mode of action. Colchicine is mainly indicated for the treatment and prophylaxis of gout and familial Mediterranean fever. Its mode of action includes modulation of chemokine and prostanoid production and inhibition of neutrophil and endothelial cell adhesion molecules by which it interferes with the initiation and amplification of the joint inflammation. This paper discusses its adverse effects and indications.

Original language	English
Pages (from-to)	252-256
Number of pages	5
Journal	Current Rheumatology Reports
Volume	4
Issue number	3
DOIs	https://doi.org/10.1007/s11926-002-0073-2
State	Published - Jun 2002
Externally published	Yes

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10.1007/s11926-002-0073-2

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Update on colchicine and its mechanism of action.

Abstract

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