Update of fecal markers of inflammation in inflammatory bowel disease

Thomas A. Judd, Andrew S. Day, Daniel A. Lemberg, Dan Turner, Steven T. Leach

Research output: Contribution to journalReview articlepeer-review

Abstract

The diagnosis, prognosis, and assessment of disease activity of inflammatory bowel disease (IBD) require investigating clinical, radiological, and histological criteria, as well as serum inflammatory markers. However, a range of fecal inflammatory markers now appears to have the potential to greatly assist in these processes. Calprotectin, a prominent neutrophil protein, was identified two decades ago as a potentially revolutionary marker for IBD. Following this discovery, numerous additional markers, including S100A12, lactoferrin, and M2-pyruvate kinase, have also been suggested as novel markers of IBD. In the present study, we provide an up-to-date review of fecal markers of IBD, and further, provide a novel analysis of each of these fecal markers in severe ulcerative colitis and compare their expression pattern in contrast to calprotectin.

Original languageEnglish
Pages (from-to)1493-1499
Number of pages7
JournalJournal of Gastroenterology and Hepatology (Australia)
Volume26
Issue number10
DOIs
StatePublished - Oct 2011
Externally publishedYes

Keywords

  • Calprotectin
  • Fecal marker
  • Inflammatory bowel disease
  • Lactoferrin
  • M2-pyruvate kinase
  • S100A12

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