Up-regulatory effect of triphasic oral contraceptive on platelet 3H-imipramine binding sites

Abraham Weizman, Hannah Morgenstern, Boris Kaplan, Zamir Amiri, Sam Tyano, Yardena Ovadia, Moshe Rehavi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Triphasic oral contraceptive (Logynon) induced a significant increase (36%) in the maximal binding capacity of platelet membranes for [3H]imipramine. The increase was achieved in the second Logynon cycle as compared to pretreatment and first Logynon cycle binding values. The pill contains a combination of ethinyl estradiol and levonorgestrel, and it is as yet unclear which of the two hormones is responsible for the up-regulatory effect. The increase in the density of platelet imipramine binding sites may reflect a similar alteration in brain. The increase in imipramine binding did not correlate with alteration in mood as assessed by Beck Depression Inventory scores.

Original languageEnglish
Pages (from-to)23-29
Number of pages7
JournalPsychiatry Research
Volume23
Issue number1
DOIs
StatePublished - Jan 1988

Keywords

  • Oral contraceptive
  • ethinyl estradiol
  • platelets
  • progesterone
  • tricyclic antidepressants

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