Up-regulatory effect of triphasic oral contraceptive on platelet 3H-imipramine binding sites

Abraham Weizman; Hannah Morgenstern; Boris Kaplan; Zamir Amiri; Sam Tyano; Yardena Ovadia; Moshe Rehavi

doi:10.1016/0165-1781(88)90031-5

Up-regulatory effect of triphasic oral contraceptive on platelet ³H-imipramine binding sites

Abraham Weizman, Hannah Morgenstern, Boris Kaplan, Zamir Amiri, Sam Tyano, Yardena Ovadia, Moshe Rehavi^*

^*Corresponding author for this work

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Triphasic oral contraceptive (Logynon) induced a significant increase (36%) in the maximal binding capacity of platelet membranes for [³H]imipramine. The increase was achieved in the second Logynon cycle as compared to pretreatment and first Logynon cycle binding values. The pill contains a combination of ethinyl estradiol and levonorgestrel, and it is as yet unclear which of the two hormones is responsible for the up-regulatory effect. The increase in the density of platelet imipramine binding sites may reflect a similar alteration in brain. The increase in imipramine binding did not correlate with alteration in mood as assessed by Beck Depression Inventory scores.

Original language	English
Pages (from-to)	23-29
Number of pages	7
Journal	Psychiatry Research
Volume	23
Issue number	1
DOIs	https://doi.org/10.1016/0165-1781(88)90031-5
State	Published - Jan 1988

Funding

Funders	Funder number
Charles E. Smith Family Foundation	6-87-6
Israel Institute for Psychobiology
Schreiber Foundation
United States-Israel BSF	84-00361

Keywords

Oral contraceptive
ethinyl estradiol
platelets
progesterone
tricyclic antidepressants

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/0165-1781(88)90031-5

Cite this

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title = "Up-regulatory effect of triphasic oral contraceptive on platelet 3H-imipramine binding sites",

abstract = "Triphasic oral contraceptive (Logynon) induced a significant increase (36%) in the maximal binding capacity of platelet membranes for [3H]imipramine. The increase was achieved in the second Logynon cycle as compared to pretreatment and first Logynon cycle binding values. The pill contains a combination of ethinyl estradiol and levonorgestrel, and it is as yet unclear which of the two hormones is responsible for the up-regulatory effect. The increase in the density of platelet imipramine binding sites may reflect a similar alteration in brain. The increase in imipramine binding did not correlate with alteration in mood as assessed by Beck Depression Inventory scores.",

keywords = "Oral contraceptive, ethinyl estradiol, platelets, progesterone, tricyclic antidepressants",

author = "Abraham Weizman and Hannah Morgenstern and Boris Kaplan and Zamir Amiri and Sam Tyano and Yardena Ovadia and Moshe Rehavi",

note = "Funding Information: Acknowledgment. This researchw ass upportedb y grants from the Schreiber Foundation, the United States-Israel BSF (grant no. 84-00361) and from the Israel Institute for Psychobiology, Charles E. Smith Family Foundation (grant no. 6-87-6) to Moshe Rehavi.",

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AU - Kaplan, Boris

AU - Amiri, Zamir

AU - Tyano, Sam

AU - Ovadia, Yardena

AU - Rehavi, Moshe

N1 - Funding Information: Acknowledgment. This researchw ass upportedb y grants from the Schreiber Foundation, the United States-Israel BSF (grant no. 84-00361) and from the Israel Institute for Psychobiology, Charles E. Smith Family Foundation (grant no. 6-87-6) to Moshe Rehavi.

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