Unusual renal deposit in mixed connective tissue disease

E. Kessler, M. Halpern, A. Chagnac, D. Zevin, I. Hammel, M. B. Bassat

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


We describe a patient with clinical signs of mixed connective tissue disease who developed nephrotic syndrome. The kidney biopsy revealed glomerular and vascular deposits that stained positive with Congo red and showed a green birefringence. The Congo red positivity became negative in sections treated with potassium permanganate. Peroxidase-antiperoxidase staining with anti-AA antibodies was strongly positive. Ultrastructurally, although the deposits were similar to amyloid, they were about twice the size of amyloid fibrils. To our knowledge, the deposition of an amyloidlike material that shows the histochemical and immunohistochemical features of amyloid AA but is lacking the distinctive ultrastructural characteristics of amyloid fibrils has not been described.

Original languageEnglish
Pages (from-to)261-264
Number of pages4
JournalArchives of Pathology and Laboratory Medicine
Issue number3
StatePublished - 1992
Externally publishedYes


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