Unusual progression and subsequent improvement in cystic lung disease in a child with radiation-induced lung injury

Michael S. Wolf, Ashley D. Chadha, Clinton M. Carroll, Scott C. Borinstein, Lisa R. Young*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Radiation-induced lung disease is a known complication of therapeutic lung irradiation, but the features have not been well described in children. We report the clinical, radiologic and histologic features of interstitial lung disease (ILD) in a 4-year-old child who had previously received lung irradiation as part of successful treatment for metastatic Wilms tumor. Her radiologic abnormalities and clinical symptoms developed in an indolent manner. Clinical improvement gradually occurred with corticosteroid therapy. However, the observed radiologic progression from interstitial and reticulonodular opacities to diffuse cystic lung disease, with subsequent improvement, is striking and has not been previously described in children.

Original languageEnglish
Pages (from-to)1086-1090
Number of pages5
JournalPediatric Radiology
Volume45
Issue number7
DOIs
StatePublished - 1 Jul 2015
Externally publishedYes

Funding

FundersFunder number
National Institutes of HealthHL119503
National Cancer InstituteK12CA090625

    Keywords

    • Child
    • Cystic lung disease
    • Interstitial lung disease
    • Lung biopsy
    • Radiation pneumonitis
    • Wilms tumor

    Fingerprint

    Dive into the research topics of 'Unusual progression and subsequent improvement in cystic lung disease in a child with radiation-induced lung injury'. Together they form a unique fingerprint.

    Cite this