Unusual leptomeningeal dissemination in a child with extracranial metastatic alveolar rhabdomyosarcoma

Myriam Weyl Ben Arush; Yehuda Kollender; Josephine Issakov; Rachel Bar Shalom; Yehudit Ben Arieh; Leonid Malkin; Sergey Postovsky

doi:10.1080/08880010902993218

Unusual leptomeningeal dissemination in a child with extracranial metastatic alveolar rhabdomyosarcoma

Myriam Weyl Ben Arush, Yehuda Kollender, Josephine Issakov, Rachel Bar Shalom, Yehudit Ben Arieh, Leonid Malkin, Sergey Postovsky

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The authors describe a 6-year-old boy diagnosed with alveolar rhabdomyosarcoma located in the thigh, with distal metastases to lungs, bones, and bone marrow. A very good partial response to first-line chemotherapy was obtained, but the child developed fatal leptomeningeal dissemination immediately after complete resection of the primary tumor. This case demonstrates the rapidity with which leptomeningeal spread of extracranial metastatic alveolar rhabdomyosarcoma can occur and underscores the importance of diagnostic lumbar puncture and brain radiological investigations at diagnosis, even when the tumors are not in the parameningeal location.

Original language	English
Pages (from-to)	473-478
Number of pages	6
Journal	Pediatric Hematology and Oncology
Volume	26
Issue number	6
DOIs	https://doi.org/10.1080/08880010902993218
State	Published - 2009
Externally published	Yes

Keywords

Alveolar rhabdomyosarcoma
Bone marrow involvement
Leptomeningeal spread

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/08880010902993218

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title = "Unusual leptomeningeal dissemination in a child with extracranial metastatic alveolar rhabdomyosarcoma",

abstract = "The authors describe a 6-year-old boy diagnosed with alveolar rhabdomyosarcoma located in the thigh, with distal metastases to lungs, bones, and bone marrow. A very good partial response to first-line chemotherapy was obtained, but the child developed fatal leptomeningeal dissemination immediately after complete resection of the primary tumor. This case demonstrates the rapidity with which leptomeningeal spread of extracranial metastatic alveolar rhabdomyosarcoma can occur and underscores the importance of diagnostic lumbar puncture and brain radiological investigations at diagnosis, even when the tumors are not in the parameningeal location.",

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AU - Arush, Myriam Weyl Ben

AU - Kollender, Yehuda

AU - Issakov, Josephine

AU - Shalom, Rachel Bar

AU - Arieh, Yehudit Ben

AU - Malkin, Leonid

AU - Postovsky, Sergey

PY - 2009

Y1 - 2009

N2 - The authors describe a 6-year-old boy diagnosed with alveolar rhabdomyosarcoma located in the thigh, with distal metastases to lungs, bones, and bone marrow. A very good partial response to first-line chemotherapy was obtained, but the child developed fatal leptomeningeal dissemination immediately after complete resection of the primary tumor. This case demonstrates the rapidity with which leptomeningeal spread of extracranial metastatic alveolar rhabdomyosarcoma can occur and underscores the importance of diagnostic lumbar puncture and brain radiological investigations at diagnosis, even when the tumors are not in the parameningeal location.

AB - The authors describe a 6-year-old boy diagnosed with alveolar rhabdomyosarcoma located in the thigh, with distal metastases to lungs, bones, and bone marrow. A very good partial response to first-line chemotherapy was obtained, but the child developed fatal leptomeningeal dissemination immediately after complete resection of the primary tumor. This case demonstrates the rapidity with which leptomeningeal spread of extracranial metastatic alveolar rhabdomyosarcoma can occur and underscores the importance of diagnostic lumbar puncture and brain radiological investigations at diagnosis, even when the tumors are not in the parameningeal location.

KW - Alveolar rhabdomyosarcoma

KW - Bone marrow involvement

KW - Leptomeningeal spread

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Unusual leptomeningeal dissemination in a child with extracranial metastatic alveolar rhabdomyosarcoma

Abstract

Keywords

UN SDGs

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