Unusual bleeding manifestations of amyloidosis in patients with multiple myeloma

M. RAPOPORT, R. YONA, S. KAUFMAN, M. SEGAL, A. KORNBERG

Research output: Contribution to journalArticlepeer-review

Abstract

Summary. We describe two patients who developed severe haemorrhagic complications. One manifested massive vaginal bleeding and the second haemopericardium with cardiac tamponade. In both cases histopathological examination showed subendothelial deposits of amyloid. Since other local and systemic causes of the haemorrhagic complications were excluded the bleeding was most probably due to amyloid angiopathy. Therefore, amyloid angiopathy should be considered in the differential diagnosis of bleeding in patients with amyloidosis associated with multiple myeloma.

Original languageEnglish
Pages (from-to)349-353
Number of pages5
JournalInternational Journal of Laboratory Hematology
Volume16
Issue number4
DOIs
StatePublished - Dec 1994

Keywords

  • amyloidosis
  • haemopericardium
  • multiple myeloma
  • vaginal bleeding

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