Untangling Photofaradaic and Photocapacitive Effects in Organic Optoelectronic Stimulation Devices

Vedran Ðerek, David Rand, Ludovico Migliaccio, Yael Hanein, Eric Daniel Głowacki*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Light, as a versatile and non-invasive means to elicit a physiological response, offers solutions to problems in basic research as well as in biomedical technologies. The complexity and limitations of optogenetic methods motivate research and development of optoelectronic alternatives. A recently growing subset of approaches relies on organic semiconductors as the active light absorber. Organic semiconductors stand out due to their high optical absorbance coefficients, mechanical flexibility, ability to operate in a wet environment, and potential biocompatibility. They could enable ultrathin and minimally invasive form factors not accessible with traditional inorganic materials. Organic semiconductors, upon photoexcitation in an aqueous medium, can transduce light into (1) photothermal heating, (2) photochemical/photocatalytic redox reactions, (3) photocapacitive charging of electrolytic double layers, and (4) photofaradaic reactions. In realistic conditions, different effects may coexist, and understanding their role in observed physiological phenomena is an area of critical interest. This article serves to evaluate the emerging picture of photofaradaic vs. photocapacitive effects in the context of our group’s research efforts and that of others over the past few years. We present simple experiments which can be used to benchmark organic optoelectronic stimulation devices.

Original languageEnglish
Article number284
JournalFrontiers in Bioengineering and Biotechnology
Volume8
DOIs
StatePublished - 17 Apr 2020

Funding

FundersFunder number
Marie Jakesova
Wallenberg Centre for Molecular Medicine at Linköping University
Stiftelsen för Strategisk Forskning
Knut och Alice Wallenbergs Stiftelse
Vetenskapsrådet2018-04505
Hrvatska Zaklada za ZnanostUIP-2019-04-1753

    Keywords

    • bioelectronics
    • neurostimulation
    • organic electronics
    • photoelectrochemistry
    • photostimulation

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