TY - JOUR
T1 - Unsuspected uterine leiomyosarcoma discovered during treatment with a gonadotropin-releasing hormone analogue
T2 - A case report and literature review
AU - Milman, D.
AU - Zalel, Y.
AU - Biran, H.
AU - Open, M.
AU - Caspi, B.
AU - Hagay, Z.
AU - Dgani, R.
PY - 1998/2/1
Y1 - 1998/2/1
N2 - We report a case of a 37-year-old woman who had received five courses of gonadotropin-releasing hormone (GnRH) agonist (Decapeptyl) for presumed uterine leiomyomata associated with episodes of uterine bleeding. Submucous myoma (histologically proven) was partially removed on the first visit. After a period of significant reduction in the tumor size and cessation of uterine bleeding, the symptoms recurred along with rapid re-growth of the uterus. Total abdominal hysterectomy was performed and the pathologic evaluation revealed leiomyosarcoma with a high mitotic rate. This case and the literature review emphasize the problems encountered with the early diagnosis of uterine leiomyosarcoma during GnRH, agonist therapy.
AB - We report a case of a 37-year-old woman who had received five courses of gonadotropin-releasing hormone (GnRH) agonist (Decapeptyl) for presumed uterine leiomyomata associated with episodes of uterine bleeding. Submucous myoma (histologically proven) was partially removed on the first visit. After a period of significant reduction in the tumor size and cessation of uterine bleeding, the symptoms recurred along with rapid re-growth of the uterus. Total abdominal hysterectomy was performed and the pathologic evaluation revealed leiomyosarcoma with a high mitotic rate. This case and the literature review emphasize the problems encountered with the early diagnosis of uterine leiomyosarcoma during GnRH, agonist therapy.
UR - http://www.scopus.com/inward/record.url?scp=0032007502&partnerID=8YFLogxK
U2 - 10.1016/S0301-2115(97)00211-X
DO - 10.1016/S0301-2115(97)00211-X
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AN - SCOPUS:0032007502
VL - 76
SP - 237
EP - 240
JO - European Journal of Obstetrics, Gynecology and Reproductive Biology
JF - European Journal of Obstetrics, Gynecology and Reproductive Biology
SN - 0028-2243
IS - 2
ER -