Unsuspected uterine leiomyosarcoma discovered during treatment with a gonadotropin-releasing hormone analogue: A case report and literature review

D. Milman, Y. Zalel, H. Biran, M. Open, B. Caspi, Z. Hagay, R. Dgani

Research output: Contribution to journalArticlepeer-review

Abstract

We report a case of a 37-year-old woman who had received five courses of gonadotropin-releasing hormone (GnRH) agonist (Decapeptyl) for presumed uterine leiomyomata associated with episodes of uterine bleeding. Submucous myoma (histologically proven) was partially removed on the first visit. After a period of significant reduction in the tumor size and cessation of uterine bleeding, the symptoms recurred along with rapid re-growth of the uterus. Total abdominal hysterectomy was performed and the pathologic evaluation revealed leiomyosarcoma with a high mitotic rate. This case and the literature review emphasize the problems encountered with the early diagnosis of uterine leiomyosarcoma during GnRH, agonist therapy.

Original languageEnglish
Pages (from-to)237-240
Number of pages4
JournalEuropean Journal of Obstetrics, Gynecology and Reproductive Biology
Volume76
Issue number2
DOIs
StatePublished - 1 Feb 1998
Externally publishedYes

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