Unstable vancomycin heteroresistance is common among clinical isolates of methiciliin-resistant Staphylococcus aureus

Nottasorn Plipat*, Gilat Livni, Heidi Bertram, Richard B. Thomson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

We tested 109 unique, vancomycin-susceptible, methicillin-resistant Staphylococcus aureus (MRSA) strains for vancomycin heteroresistance by a selection method, i.e., step-wise exposure of large inoculums to increasing concentrations of vancomycin. Although no strains demonstrated stable heteroresistance, 81 strains (74%) demonstrated unstable heteroresistance. Unstable heteroresistance is common among clinical isolates of MRSA and may represent a cause of therapeutic failure.

Original languageEnglish
Pages (from-to)2494-2496
Number of pages3
JournalJournal of Clinical Microbiology
Volume43
Issue number5
DOIs
StatePublished - May 2005
Externally publishedYes

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