TY - JOUR
T1 - Unstable vancomycin heteroresistance is common among clinical isolates of methiciliin-resistant Staphylococcus aureus
AU - Plipat, Nottasorn
AU - Livni, Gilat
AU - Bertram, Heidi
AU - Thomson, Richard B.
PY - 2005/5
Y1 - 2005/5
N2 - We tested 109 unique, vancomycin-susceptible, methicillin-resistant Staphylococcus aureus (MRSA) strains for vancomycin heteroresistance by a selection method, i.e., step-wise exposure of large inoculums to increasing concentrations of vancomycin. Although no strains demonstrated stable heteroresistance, 81 strains (74%) demonstrated unstable heteroresistance. Unstable heteroresistance is common among clinical isolates of MRSA and may represent a cause of therapeutic failure.
AB - We tested 109 unique, vancomycin-susceptible, methicillin-resistant Staphylococcus aureus (MRSA) strains for vancomycin heteroresistance by a selection method, i.e., step-wise exposure of large inoculums to increasing concentrations of vancomycin. Although no strains demonstrated stable heteroresistance, 81 strains (74%) demonstrated unstable heteroresistance. Unstable heteroresistance is common among clinical isolates of MRSA and may represent a cause of therapeutic failure.
UR - http://www.scopus.com/inward/record.url?scp=18544374025&partnerID=8YFLogxK
U2 - 10.1128/JCM.43.5.2494-2496.2005
DO - 10.1128/JCM.43.5.2494-2496.2005
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C2 - 15872293
AN - SCOPUS:18544374025
SN - 0095-1137
VL - 43
SP - 2494
EP - 2496
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
IS - 5
ER -