Unrelated and related cord blood banking and hematopoietic graft engineering

Yossi Cohen, Doron Kreiser, Margarita Mayorov, Arnon Nagler*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

The first successful transplantation of umbilical-cord blood (CB) was performed in 1988 to treat a boy with Fanconi's anemia, using CB from his HLA full-matched sister. A few years later, CB transplantation (CBT) was also performed in an adult recipient, however major obstacles still prevent a wider application of CBT in this age group. The principle limiting-factor is the low numbers of nucleated (NC and CD34+ cells available for transplantation compared to a typical bone marrow (BM)/peripheral blood (PB) allograft, resulting in a lower engraftment success as well as delayed hematopoietic recovery with its characteristic complications, including infections and transplant related mortality (TRM). Other problems include uncertainty regarding potency and efficacy of graft versus leukemia (GvL)/tumor effects in this kind of transplant, considering the reduced graft versus host disease (GvHD) manifestations and immunologic prematurity. These subjects are reviewed with orientation to technical methods directed to improve CB grafts and graft engineering.

Original languageEnglish
Pages (from-to)29-35
Number of pages7
JournalCell and Tissue Banking
Volume4
Issue number1
DOIs
StatePublished - 2003
Externally publishedYes

Keywords

  • Cell dose
  • Cord blood
  • Cryopreservation
  • Ex vivo expansion
  • NK cells

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