Unraveling the Diversity of Co-Colonization by CPE

Gabrielle Levi; Mor Lurie-Weinberger; Alona Keren-Paz; Antoine O. Andremont; David Schwartz; Yehuda Carmeli

doi:10.3390/microorganisms10071292

Unraveling the Diversity of Co-Colonization by CPE

Gabrielle Levi, Mor Lurie-Weinberger, Alona Keren-Paz, Antoine O. Andremont, David Schwartz, Yehuda Carmeli^*

^*Corresponding author for this work

Internal Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Antibiotic-resistant bacteria, and more specifically, carbapenem-producing Enterobacterales (CPE) strains, are increasing worldwide. Despite their growing prevalence, in most high-income countries, the detection of CPE is still considered a low-frequency event. Sporadically, patients co-colonized with distinct CPE strains and/or different carbapenemase enzymes are detected. In this paper, we present three cases that illustrate the underlying mechanisms of co-colonization, focusing on horizontal gene transfer (HGT) and patient-to-patient transmission. We also demonstrate the diversity of CPE species and discuss the potential consequences of co-colonization.

Original language	English
Article number	1292
Journal	Microorganisms
Volume	10
Issue number	7
DOIs	https://doi.org/10.3390/microorganisms10071292
State	Published - Jul 2022

Keywords

CPE
CRE
HGT
co-colonization

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title = "Unraveling the Diversity of Co-Colonization by CPE",

abstract = "Antibiotic-resistant bacteria, and more specifically, carbapenem-producing Enterobacterales (CPE) strains, are increasing worldwide. Despite their growing prevalence, in most high-income countries, the detection of CPE is still considered a low-frequency event. Sporadically, patients co-colonized with distinct CPE strains and/or different carbapenemase enzymes are detected. In this paper, we present three cases that illustrate the underlying mechanisms of co-colonization, focusing on horizontal gene transfer (HGT) and patient-to-patient transmission. We also demonstrate the diversity of CPE species and discuss the potential consequences of co-colonization.",

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author = "Gabrielle Levi and Mor Lurie-Weinberger and Alona Keren-Paz and Andremont, {Antoine O.} and David Schwartz and Yehuda Carmeli",

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AU - Lurie-Weinberger, Mor

AU - Keren-Paz, Alona

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AU - Schwartz, David

AU - Carmeli, Yehuda

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AB - Antibiotic-resistant bacteria, and more specifically, carbapenem-producing Enterobacterales (CPE) strains, are increasing worldwide. Despite their growing prevalence, in most high-income countries, the detection of CPE is still considered a low-frequency event. Sporadically, patients co-colonized with distinct CPE strains and/or different carbapenemase enzymes are detected. In this paper, we present three cases that illustrate the underlying mechanisms of co-colonization, focusing on horizontal gene transfer (HGT) and patient-to-patient transmission. We also demonstrate the diversity of CPE species and discuss the potential consequences of co-colonization.

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Unraveling the Diversity of Co-Colonization by CPE

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