Unmet needs in the treatment of gastroesophageal reflux disease

Ram Dickman, Carla Maradey-Romero, Rachel Gingold-Belfer, Ronnie Fass*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Gastroesophageal reflux disease (GERD) is a highly prevalent gastrointestinal disorder. Proton pump inhibitors have profoundly revolutionized the treatment of GERD. However, several areas of unmet need persist despite marked improvements in the therapeutic management of GERD. These include the advanced grades of erosive esophagitis, nonerosive reflux disease, maintenance treatment of erosive esophagitis, refractory GERD, postprandial heartburn, atypical and extraesophageal manifestations of GERD, Barrett's esophagus, chronic protein pump inhibitor treatment, and post-bariatric surgery GERD. Consequently, any future development of novel therapeutic modalities for GERD (medical, endoscopic, or surgical), would likely focus on the aforementioned areas of unmet need.

Original languageEnglish
Pages (from-to)309-319
Number of pages11
JournalJournal of Neurogastroenterology and Motility
Issue number3
StatePublished - 2015
Externally publishedYes


  • Gastroesophageal reflux
  • Heartburn
  • Proton pump inhibitors


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