United States' factor XI-deficiency patients need a safer treatment

Louis M. Aledort, Jenny Goudemand, Jeannie Callum, Viviane Guerin, G. Kenet, Man Chiu Poon, Olivier Spertini, Mari Thomas

Research output: Contribution to journalReview articlepeer-review


A replacement factor for Factor XI with is virally inactivated is not available in the U.S. Elsewhere an inactivated concentrate has been used. A review of the experience over 15 years suggests that this product is safe and effective and suggests its potential use in the U.S. The most serious complication of the factor was a slight increase in DIC and thrombotic events.

Original languageEnglish
Pages (from-to)301-302
Number of pages2
JournalAmerican Journal of Hematology
Issue number4
StatePublished - Dec 2005


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