TY - JOUR
T1 - Unique imaging features enabling the prenatal diagnosis of developmental venous anomalies
T2 - A persistent echogenic brain lesion drained by a collecting vein in contrast with normal brain parenchyma on MRI
AU - Krajden Haratz, Karina
AU - Peled, Alon
AU - Weizman, Boris
AU - Gindes, Liat
AU - Tamarkin, Mordechai
AU - Lev, Dorit
AU - Kidron, Dvora
AU - Ben-Sira, Liat
AU - Malinger, Gustavo
AU - Lerman-Sagie, Tally
AU - Leibovitz, Zvi
N1 - Publisher Copyright:
© 2017S. Karger AG, Basel.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Objective: To describe the prenatal imaging features enabling diagnosis of developmental venous anomalies (DVA). Methods: Four fetuses with unexplained persistent echogenic parenchymal brain lesions were studied. The evaluation included dedicated neurosonography, fetal MRI, serology for intrauterine infection, screening for coagulation abnormalities, and chromosomal microarray. Postnatal neurodevelopmental follow-up or autopsy results were assessed. Results: DVA presented as very slowly growing echogenic brain lesions without cystic components, calcifications, or structural changes on otherwise normal neurosonographic scans performed at 2- to 3-week intervals. A specific Doppler feature was a collecting vein draining the echogenic parenchyma. Fetal brain MRI depicted normal anatomy on half-Fourier acquisition single-shot turbo spin-echo and diffusion-weighted imaging. The rest of the evaluation was normal. Conclusions: In cases with a persistent, parenchymal echogenic lesion without clastic or structural changes, DVA should be considered. Demonstration of a collecting vein draining the lesion and normal brain anatomy on MRI confirm the diagnosis.
AB - Objective: To describe the prenatal imaging features enabling diagnosis of developmental venous anomalies (DVA). Methods: Four fetuses with unexplained persistent echogenic parenchymal brain lesions were studied. The evaluation included dedicated neurosonography, fetal MRI, serology for intrauterine infection, screening for coagulation abnormalities, and chromosomal microarray. Postnatal neurodevelopmental follow-up or autopsy results were assessed. Results: DVA presented as very slowly growing echogenic brain lesions without cystic components, calcifications, or structural changes on otherwise normal neurosonographic scans performed at 2- to 3-week intervals. A specific Doppler feature was a collecting vein draining the echogenic parenchyma. Fetal brain MRI depicted normal anatomy on half-Fourier acquisition single-shot turbo spin-echo and diffusion-weighted imaging. The rest of the evaluation was normal. Conclusions: In cases with a persistent, parenchymal echogenic lesion without clastic or structural changes, DVA should be considered. Demonstration of a collecting vein draining the lesion and normal brain anatomy on MRI confirm the diagnosis.
KW - Cerebellum
KW - Dedicated neurosonography
KW - Developmental venous anomaly
KW - Fetal MRI
KW - Prenatal diagnosis
UR - http://www.scopus.com/inward/record.url?scp=85021172560&partnerID=8YFLogxK
U2 - 10.1159/000464247
DO - 10.1159/000464247
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C2 - 28624828
AN - SCOPUS:85021172560
SN - 1015-3837
VL - 43
SP - 53
EP - 60
JO - Fetal Diagnosis and Therapy
JF - Fetal Diagnosis and Therapy
IS - 1
ER -