Unilateral spiny hyperkeratosis: Case report and review of the literature

Baruch Mevorah, Andrea Gat, Haim Golan*, Sarah Brenner

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


We describe the first case of unilateral spiny hyperkeratosis (SH) of the left hand, review the literature and discuss possible patho- mechanisms. SH can be sporadic or familial, often appearing in healthy individuals. However, there is an association with various malignancies in a significant number of the sporadic cases. Although there is no satisfactory explanation of this association, we agree with previous authors that a patient with SH appearing in adult life should be evaluated and followed for the presence of malignancy. Other patients with SH may suffer from a variety of nonmalignant diseases, which may be coincidental or causally related. SH is not a premalignant lesion of the skin and should not be confused with porokeratosis which has a malignant potential. Except for excision of individual lesions, there is no permanent cure.

Original languageEnglish
Pages (from-to)181-186
Number of pages6
Issue number2
StatePublished - Aug 2008


  • Keratoderma
  • Palmoplantar keratoderma
  • Spiny hyperkeratosis


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