Unilateral Sensorineural Hearing Loss in Congenital Cytomegalovirus Retrospective Observational Study

Layah Alkoby-Meshulam*, Daisy Rosenthal-Shtern, Ori Snapiri, David Levy, Nimrod Sachs, Merav Sokolov, Efraim Bilavsky

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The leading nonhereditary cause of childhood sensorineural hearing loss has been attributed to congenital cytomegalovirus (cCMV). Sensorineural hearing loss can be unilateral (UHL) or bilateral (BHL), and may be progressive. Our objective was to describe the characteristics, clinical nature and follow-up of ears in cCMV-associated UHL. Methods: This 16-year retrospective study was performed at Schneider's Medical Center, Israel. Data were collected from all cCMV infants with UHL at birth who were treated with antiviral treatment initiated within the first 4 weeks of life and had a follow-up period of at least 1 year. Results: We enrolled 67 infants diagnosed with UHL at birth: 17 (25%) with mild hearing loss, 22 (33%) with moderate hearing loss and 28 (42%) with severe hearing loss. At the last follow-up visit, 7 (41%) ears in the mild hearing loss group improved to normal hearing, 8 (47%) ears exhibited no change and 2 (12%) ears deteriorated. In the moderate hearing loss group, 9 (41%) ears improved, 7 (32%) remained static and 6 (27%) deteriorated to the severe hearing loss group. One (4%) ear in the severe hearing loss group showed improvement. Of the 67 ears with normal hearing at birth, 4 (6%) ears deteriorated. Conclusions: This study assessed and elucidated the characteristics, clinical nature and long-term follow-up of both the affected and unaffected ears diagnosed with UHL due to cCMV. These data are crucial when medical and/or surgical interventions are considered.

Original languageEnglish
JournalPediatric Infectious Disease Journal
DOIs
StateAccepted/In press - 2024

Keywords

  • congenital CMV
  • sensorineural hearing loss
  • unilateral hearing loss

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