Unified reduction principle for the evolution of mutation, migration, and recombination

Lee Altenberg, Uri Liberman, Marcus W. Feldman

Research output: Contribution to journalArticlepeer-review


Modifier-gene models for the evolution of genetic information transmission between generations of organisms exhibit the reduction principle: Selection favors reduction in the rate of variation production in populations near equilibrium under a balance of constant viability selection and variation production. Whereas this outcome has been proven for a variety of genetic models, it has not been proven in general for multiallelic genetic models of mutation, migration, and recombination modification with arbitrary linkage between the modifier and major genes under viability selection. We show that the reduction principle holds for all of these cases by developing a unifying mathematical framework that characterizes all of these evolutionary models.

Original languageEnglish
Pages (from-to)E2392-E2400
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number12
StatePublished - 21 Mar 2017


  • Dispersal
  • External stability
  • Modifier genes
  • Mutation
  • Recombination


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