@article{f9ee700604be4e60b6a0635e302341a9,
title = "Unified reduction principle for the evolution of mutation, migration, and recombination",
abstract = "Modifier-gene models for the evolution of genetic information transmission between generations of organisms exhibit the reduction principle: Selection favors reduction in the rate of variation production in populations near equilibrium under a balance of constant viability selection and variation production. Whereas this outcome has been proven for a variety of genetic models, it has not been proven in general for multiallelic genetic models of mutation, migration, and recombination modification with arbitrary linkage between the modifier and major genes under viability selection. We show that the reduction principle holds for all of these cases by developing a unifying mathematical framework that characterizes all of these evolutionary models.",
keywords = "Dispersal, External stability, Modifier genes, Mutation, Recombination",
author = "Lee Altenberg and Uri Liberman and Feldman, {Marcus W.}",
note = "Funding Information: This work was supported in part by the Stanford Center for Computational, Evolutionary, and Human Genomics, Stanford University; the Konrad Lorenz Institute for Evolution and Cognition Research; the University of Hawaii at Manoa; and the Mathematical Biosciences Institute through National Science Foundation Award DMS 0931642.",
year = "2017",
month = mar,
day = "21",
doi = "10.1073/pnas.1619655114",
language = "אנגלית",
volume = "114",
pages = "E2392--E2400",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
publisher = "National Academy of Sciences",
number = "12",
}