TY - JOUR
T1 - Unexplained repeated pregnancy loss is associated with altered perceptual and brain responses to men’s body-odor
AU - Rozenkrantz, Liron
AU - Weissgross, Reut
AU - Weiss, Tali
AU - Ravreby, Inbal
AU - Frumin, Idan
AU - Shushan, Sagit
AU - Gorodisky, Lior
AU - Reshef, Netta
AU - Holzman, Yael
AU - Pinchover, Liron
AU - Endevelt-Shapira, Yaara
AU - Mishor, Eva
AU - Soroka, Timna
AU - Finkel, Maya
AU - Tagania, Liav
AU - Ravia, Aharon
AU - Perl, Ofer
AU - Furman-Haran, Edna
AU - Carp, Howard
AU - Sobel, Noam
N1 - Publisher Copyright:
© Rozenkrantz et al.
PY - 2020/9
Y1 - 2020/9
N2 - Mammalian olfaction and reproduction are tightly linked, a link less explored in humans. Here, we asked whether human unexplained repeated pregnancy loss (uRPL) is associated with altered olfaction, and particularly altered olfactory responses to body-odor. We found that whereas most women with uRPL could identify the body-odor of their spouse, most control women could not. Moreover, women with uRPL rated the perceptual attributes of men’s body-odor differently from controls. These pronounced differences were accompanied by an only modest albeit significant advantage in ordinary, non-body-odor-related olfaction in uRPL. Next, using structural and functional brain imaging, we found that in comparison to controls, most women with uRPL had smaller olfactory bulbs, yet increased hypothalamic response in association with men’s body-odor. These findings combine to suggest altered olfactory perceptual and brain responses in women experiencing uRPL, particularly in relation to men’s body-odor. Whether this link has any causal aspects to it remains to be explored.
AB - Mammalian olfaction and reproduction are tightly linked, a link less explored in humans. Here, we asked whether human unexplained repeated pregnancy loss (uRPL) is associated with altered olfaction, and particularly altered olfactory responses to body-odor. We found that whereas most women with uRPL could identify the body-odor of their spouse, most control women could not. Moreover, women with uRPL rated the perceptual attributes of men’s body-odor differently from controls. These pronounced differences were accompanied by an only modest albeit significant advantage in ordinary, non-body-odor-related olfaction in uRPL. Next, using structural and functional brain imaging, we found that in comparison to controls, most women with uRPL had smaller olfactory bulbs, yet increased hypothalamic response in association with men’s body-odor. These findings combine to suggest altered olfactory perceptual and brain responses in women experiencing uRPL, particularly in relation to men’s body-odor. Whether this link has any causal aspects to it remains to be explored.
UR - http://www.scopus.com/inward/record.url?scp=85092060332&partnerID=8YFLogxK
U2 - 10.7554/ELIFE.55305
DO - 10.7554/ELIFE.55305
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C2 - 32988456
AN - SCOPUS:85092060332
SN - 2050-084X
VL - 9
SP - 1
EP - 23
JO - eLife
JF - eLife
M1 - e55305
ER -