Unearthing Neanderthal population history using nuclear and mitochondrial DNA from cave sediments

Benjamin Vernot; Elena I. Zavala; Asier Gómez-Olivencia; Zenobia Jacobs; Viviane Slon; Fabrizio Mafessoni; Frédéric Romagné; Alice Pearson; Martin Petr; Nohemi Sala; Adrián Pablos; Arantza Aranbur; José Mariá Bermúdez De Castro; Eudald Carbonell; Bo Li; MacIej T. Krajcarz; Andrey I. Krivoshapkin; Kseniya A. Kolobova; Maxim B. Kozlikin; Michael V. Shunkov; Anatoly P. Derevianko; Bence Viola; Steffi Grote; Elena Essel; David López Herraéz; Sarah Nagel; Birgit Nickel; Julia Richter; Anna Schmidt; Benjamin Peter; Janet Kelso; Richard G. Roberts; Juan Luis Arsuaga; Matthias Meyer

doi:10.1126/science.abf1667

Unearthing Neanderthal population history using nuclear and mitochondrial DNA from cave sediments

Benjamin Vernot^*, Elena I. Zavala, Asier Gómez-Olivencia, Zenobia Jacobs, Viviane Slon, Fabrizio Mafessoni, Frédéric Romagné, Alice Pearson, Martin Petr, Nohemi Sala, Adrián Pablos, Arantza Aranbur, José Mariá Bermúdez De Castro, Eudald Carbonell, Bo Li, MacIej T. Krajcarz, Andrey I. Krivoshapkin, Kseniya A. Kolobova, Maxim B. Kozlikin, Michael V. ShunkovAnatoly P. Derevianko, Bence Viola, Steffi Grote, Elena Essel, David López Herraéz, Sarah Nagel, Birgit Nickel, Julia Richter, Anna Schmidt, Benjamin Peter, Janet Kelso, Richard G. Roberts, Juan Luis Arsuaga, Matthias Meyer^*

^*Corresponding author for this work

Anatomy and Anthropology

Research output: Contribution to journal › Article › peer-review

96 Scopus citations

Abstract

Bones and teeth are important sources of Pleistocene hominin DNA, but are rarely recovered at archaeological sites. Mitochondrial DNA (mtDNA) has been retrieved from cave sediments but provides limited value for studying population relationships. We therefore developed methods for the enrichment and analysis of nuclear DNA from sediments and applied them to cave deposits in western Europe and southern Siberia dated to between 200,000 and 50,000 years ago. We detected a population replacement in northern Spain about 100,000 years ago, which was accompanied by a turnover of mtDNA. We also identified two radiation events in Neanderthal history during the early part of the Late Pleistocene. Our work lays the ground for studying the population history of ancient hominins from trace amounts of nuclear DNA in sediments.

Original language	English
Article number	590
Journal	Science
Volume	372
Issue number	6542
DOIs	https://doi.org/10.1126/science.abf1667
State	Published - 7 May 2021

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Vernot, B., Zavala, E. I., Gómez-Olivencia, A., Jacobs, Z., Slon, V., Mafessoni, F., Romagné, F., Pearson, A., Petr, M., Sala, N., Pablos, A., Aranbur, A., De Castro, J. M. B., Carbonell, E., Li, B., Krajcarz, M. T., Krivoshapkin, A. I., Kolobova, K. A., Kozlikin, M. B., ... Meyer, M. (2021). Unearthing Neanderthal population history using nuclear and mitochondrial DNA from cave sediments. Science, 372(6542), Article 590. https://doi.org/10.1126/science.abf1667

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title = "Unearthing Neanderthal population history using nuclear and mitochondrial DNA from cave sediments",

abstract = "Bones and teeth are important sources of Pleistocene hominin DNA, but are rarely recovered at archaeological sites. Mitochondrial DNA (mtDNA) has been retrieved from cave sediments but provides limited value for studying population relationships. We therefore developed methods for the enrichment and analysis of nuclear DNA from sediments and applied them to cave deposits in western Europe and southern Siberia dated to between 200,000 and 50,000 years ago. We detected a population replacement in northern Spain about 100,000 years ago, which was accompanied by a turnover of mtDNA. We also identified two radiation events in Neanderthal history during the early part of the Late Pleistocene. Our work lays the ground for studying the population history of ancient hominins from trace amounts of nuclear DNA in sediments.",

author = "Benjamin Vernot and Zavala, {Elena I.} and Asier G{\'o}mez-Olivencia and Zenobia Jacobs and Viviane Slon and Fabrizio Mafessoni and Fr{\'e}d{\'e}ric Romagn{\'e} and Alice Pearson and Martin Petr and Nohemi Sala and Adri{\'a}n Pablos and Arantza Aranbur and {De Castro}, {Jos{\'e} Mari{\'a} Berm{\'u}dez} and Eudald Carbonell and Bo Li and Krajcarz, {MacIej T.} and Krivoshapkin, {Andrey I.} and Kolobova, {Kseniya A.} and Kozlikin, {Maxim B.} and Shunkov, {Michael V.} and Derevianko, {Anatoly P.} and Bence Viola and Steffi Grote and Elena Essel and Herra{\'e}z, {David L{\'o}pez} and Sarah Nagel and Birgit Nickel and Julia Richter and Anna Schmidt and Benjamin Peter and Janet Kelso and Roberts, {Richard G.} and Arsuaga, {Juan Luis} and Matthias Meyer",

year = "2021",

month = may,

day = "7",

doi = "10.1126/science.abf1667",

language = "אנגלית",

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journal = "Science",

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Vernot, B, Zavala, EI, Gómez-Olivencia, A, Jacobs, Z, Slon, V, Mafessoni, F, Romagné, F, Pearson, A, Petr, M, Sala, N, Pablos, A, Aranbur, A, De Castro, JMB, Carbonell, E, Li, B, Krajcarz, MT, Krivoshapkin, AI, Kolobova, KA, Kozlikin, MB, Shunkov, MV, Derevianko, AP, Viola, B, Grote, S, Essel, E, Herraéz, DL, Nagel, S, Nickel, B, Richter, J, Schmidt, A, Peter, B, Kelso, J, Roberts, RG, Arsuaga, JL & Meyer, M 2021, 'Unearthing Neanderthal population history using nuclear and mitochondrial DNA from cave sediments', Science, vol. 372, no. 6542, 590. https://doi.org/10.1126/science.abf1667

TY - JOUR

T1 - Unearthing Neanderthal population history using nuclear and mitochondrial DNA from cave sediments

AU - Vernot, Benjamin

AU - Zavala, Elena I.

AU - Gómez-Olivencia, Asier

AU - Jacobs, Zenobia

AU - Slon, Viviane

AU - Mafessoni, Fabrizio

AU - Romagné, Frédéric

AU - Pearson, Alice

AU - Petr, Martin

AU - Sala, Nohemi

AU - Pablos, Adrián

AU - Aranbur, Arantza

AU - De Castro, José Mariá Bermúdez

AU - Carbonell, Eudald

AU - Li, Bo

AU - Krajcarz, MacIej T.

AU - Krivoshapkin, Andrey I.

AU - Kolobova, Kseniya A.

AU - Kozlikin, Maxim B.

AU - Shunkov, Michael V.

AU - Derevianko, Anatoly P.

AU - Viola, Bence

AU - Grote, Steffi

AU - Essel, Elena

AU - Herraéz, David López

AU - Nagel, Sarah

AU - Nickel, Birgit

AU - Richter, Julia

AU - Schmidt, Anna

AU - Peter, Benjamin

AU - Kelso, Janet

AU - Roberts, Richard G.

AU - Arsuaga, Juan Luis

AU - Meyer, Matthias

PY - 2021/5/7

Y1 - 2021/5/7

N2 - Bones and teeth are important sources of Pleistocene hominin DNA, but are rarely recovered at archaeological sites. Mitochondrial DNA (mtDNA) has been retrieved from cave sediments but provides limited value for studying population relationships. We therefore developed methods for the enrichment and analysis of nuclear DNA from sediments and applied them to cave deposits in western Europe and southern Siberia dated to between 200,000 and 50,000 years ago. We detected a population replacement in northern Spain about 100,000 years ago, which was accompanied by a turnover of mtDNA. We also identified two radiation events in Neanderthal history during the early part of the Late Pleistocene. Our work lays the ground for studying the population history of ancient hominins from trace amounts of nuclear DNA in sediments.

AB - Bones and teeth are important sources of Pleistocene hominin DNA, but are rarely recovered at archaeological sites. Mitochondrial DNA (mtDNA) has been retrieved from cave sediments but provides limited value for studying population relationships. We therefore developed methods for the enrichment and analysis of nuclear DNA from sediments and applied them to cave deposits in western Europe and southern Siberia dated to between 200,000 and 50,000 years ago. We detected a population replacement in northern Spain about 100,000 years ago, which was accompanied by a turnover of mtDNA. We also identified two radiation events in Neanderthal history during the early part of the Late Pleistocene. Our work lays the ground for studying the population history of ancient hominins from trace amounts of nuclear DNA in sediments.

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U2 - 10.1126/science.abf1667

DO - 10.1126/science.abf1667

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C2 - 33858989

AN - SCOPUS:85105400983

SN - 0036-8075

VL - 372

JO - Science

JF - Science

IS - 6542

M1 - 590

ER -

Unearthing Neanderthal population history using nuclear and mitochondrial DNA from cave sediments

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