Undifferentiated spleen colonies: An attempt to induce differentiation into eosinophils

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Repeated injections of casein caused a 4 fold increase in the overall number of colonies in the spleens of sublethally irradiated, polycythemic mice. Chronic (12 injections) casein treatment considerably increased the number of eosinophil and of undifferentiated colonies, but not that of granuloid ones. A reduction in number and size of eosinophil colonies took place between the sixth and the ninth day after irradiation. No such reduction occurred with undifferentiated colonies. Stimulation with casein for only 3 (consecutive) days before irradiation caused a similar increase in eosinophil colonies, only a moderate increase in undifferentiated ones and a very marked increase in granuloid colonies. There was no evidence for a change of undifferentiated colonies into eosinophil ones under conditions of eosinopoiesis. No correlation was found between the amyloid inducing capacity of caseins and their eosinopoietic potency.

Original languageEnglish
Pages (from-to)267-273
Number of pages7
JournalRES Journal of the Reticuloendothelial Society
Issue number5
StatePublished - 1975


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