Uncommon side effects of common drugs in patients with familial dysautonomia

Liat Perl, David Hakimian, Channa Maayan, David Rekhtman, Elchanan Fried, Mali Salmon-Divon, Daniel Mark Sapozhnikov, David Cheishvili*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Purpose: Patients with the autosomal recessive disorder of familial dysautonomia typically exhibit exacerbated adverse side effects to many common drugs. We aimed to catalog these adverse effects – with a focus on common drugs that are frequently administered to FD patients and compare their incidences to those within the general population. Methods: We used data of 595 FD patients from an international database with information on drugs received and adverse effects. To investigate the molecular causes of reported differences in drug responses in FD patients, we used expression microarrays to compare the mRNA expression profiles in peripheral blood leukocytes of FD patients (n = 12) and healthy individuals (n = 10). Results: Several drug classes, including cholinergics, anti-cholinergics, anti-convulsants, methylxanthines, SSRIs, and antibiotics caused either unreported symptoms or elevated rates of adverse events in FD patients. FD patients experienced different or more frequent adverse side effects than the general population in 31/123 drugs. These side effects included blood cell dyscrasias, amenorrhea, gastrointestinal bleeding, and bronchospasm. New findings include enhanced reaction of FD patients to H2 antagonist agents and to serotonin receptor agonists. We also detected eight genes differentially expressed between FD patients and healthy individuals that may underlie the differential drug responses of FD patients. Conclusion: We provide evidence that suggests the use of several common drugs should be discontinued or reduced in FD patients.

Original languageEnglish
Pages (from-to)128-140
Number of pages13
JournalPharmacoepidemiology and Drug Safety
Volume31
Issue number2
DOIs
StatePublished - Feb 2022

Funding

FundersFunder number
Dysautonomia Foundation

    Fingerprint

    Dive into the research topics of 'Uncommon side effects of common drugs in patients with familial dysautonomia'. Together they form a unique fingerprint.

    Cite this