Unaltered platelet [3h]-imipramine binding in dementia of the alzheimer type

Ronit Weizman; Jacob Dick; Abraham Mosek; Sam Tyano; Moshe Rehavi

doi:10.1159/000118437

Unaltered platelet [³h]-imipramine binding in dementia of the alzheimer type

Ronit Weizman, Jacob Dick, Abraham Mosek, Sam Tyano, Moshe Rehavi^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

High-affinity [³H]-imipramine binding to platelets was evaluated in 11 patients suffering from dementia of Alzheimer type (DAT) in comparison to 12 normal controls. The [³H]-imipramine binding values (B_max and K_d) did not differ between the DAT patients and the controls. Previous studies have demonstrated hypofunction of central serotonergic system in this disease, including reduced imipramine binding to brain. Thus, it seems that the low imipramine binding in DAT is confined to the brain tissue and not reflected in the platelets.

Original language	English
Pages (from-to)	69-72
Number of pages	4
Journal	Neuropsychobiology
Volume	19
Issue number	2
DOIs	https://doi.org/10.1159/000118437
State	Published - 1988

Keywords

Alzheimer’s disease
Platelets
Serotonin
[H]-Imipramine

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title = "Unaltered platelet [3h]-imipramine binding in dementia of the alzheimer type",

abstract = "High-affinity [3H]-imipramine binding to platelets was evaluated in 11 patients suffering from dementia of Alzheimer type (DAT) in comparison to 12 normal controls. The [3H]-imipramine binding values (Bmax and Kd) did not differ between the DAT patients and the controls. Previous studies have demonstrated hypofunction of central serotonergic system in this disease, including reduced imipramine binding to brain. Thus, it seems that the low imipramine binding in DAT is confined to the brain tissue and not reflected in the platelets.",

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AU - Rehavi, Moshe

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AB - High-affinity [3H]-imipramine binding to platelets was evaluated in 11 patients suffering from dementia of Alzheimer type (DAT) in comparison to 12 normal controls. The [3H]-imipramine binding values (Bmax and Kd) did not differ between the DAT patients and the controls. Previous studies have demonstrated hypofunction of central serotonergic system in this disease, including reduced imipramine binding to brain. Thus, it seems that the low imipramine binding in DAT is confined to the brain tissue and not reflected in the platelets.

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KW - Platelets

KW - Serotonin

KW - [H]-Imipramine

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Unaltered platelet [³h]-imipramine binding in dementia of the alzheimer type

Abstract

Keywords

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