Ultrastructural Features of the Granulocytes in Down's Syndrome

M. Djaldetti*, H. Bessler, P. Fishman, E. van der Lÿn, H. Joshua

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The granulocytes of 9 patients with Down's syndrome (DS) were examined for morphological abnormalities. Electron microscope examination showed abnormalities in the nucleus, such as pockets, bridges, appendices and fibrillar bodies in 25–57 % of the cells as compared to similar, but less conspicuous findings in 5–10 % of the granulocytes of 5 controls. The similarity of these ultrastructural malformations to those described in different forms of leukaemia is stressed. Since chromosomal abnormalities exist in both DS and leukaemia, the possibility that they are the cause for the ultrastructural alterations is discussed.

Original languageEnglish
Pages (from-to)104-111
Number of pages8
JournalScandinavian Journal of Haematology
Issue number2
StatePublished - Feb 1974


Dive into the research topics of 'Ultrastructural Features of the Granulocytes in Down's Syndrome'. Together they form a unique fingerprint.

Cite this