TY - JOUR
T1 - Ultrastructural Features of the Granulocytes in Down's Syndrome
AU - Djaldetti, M.
AU - Bessler, H.
AU - Fishman, P.
AU - van der Lÿn, E.
AU - Joshua, H.
PY - 1974/2
Y1 - 1974/2
N2 - The granulocytes of 9 patients with Down's syndrome (DS) were examined for morphological abnormalities. Electron microscope examination showed abnormalities in the nucleus, such as pockets, bridges, appendices and fibrillar bodies in 25–57 % of the cells as compared to similar, but less conspicuous findings in 5–10 % of the granulocytes of 5 controls. The similarity of these ultrastructural malformations to those described in different forms of leukaemia is stressed. Since chromosomal abnormalities exist in both DS and leukaemia, the possibility that they are the cause for the ultrastructural alterations is discussed.
AB - The granulocytes of 9 patients with Down's syndrome (DS) were examined for morphological abnormalities. Electron microscope examination showed abnormalities in the nucleus, such as pockets, bridges, appendices and fibrillar bodies in 25–57 % of the cells as compared to similar, but less conspicuous findings in 5–10 % of the granulocytes of 5 controls. The similarity of these ultrastructural malformations to those described in different forms of leukaemia is stressed. Since chromosomal abnormalities exist in both DS and leukaemia, the possibility that they are the cause for the ultrastructural alterations is discussed.
UR - http://www.scopus.com/inward/record.url?scp=0016372898&partnerID=8YFLogxK
U2 - 10.1111/j.1600-0609.1974.tb00188.x
DO - 10.1111/j.1600-0609.1974.tb00188.x
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C2 - 4275399
AN - SCOPUS:0016372898
SN - 0036-553X
VL - 12
SP - 104
EP - 111
JO - Scandinavian Journal of Haematology
JF - Scandinavian Journal of Haematology
IS - 2
ER -