Ultrastructural Features of Bone Marrow Cells from Patients with Acquired Sideroblastic Anemia

Meir Djaldetti*, Michael Bergman, Hertzel Salman, Amos M. Cohen, Hanna Bessler

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


The ultrastructural findings of the bone marrow cells from 15 patients with acquired sideroblastic anemia are presented. The red cell precursors from all patients showed the presence of electron-dense material in the mitochondria, representing most probably iron deposits. A great number of these mitochondria were completely destroyed. The erythropoietic precursors from one of the patients showed markedly elongated mitochondria that measured up to 3 μm. In addition numerous cytoplasmic vacuoles were observed. The red cell precursors from 60% of the patients showed signs of dyserythropoiesis, such as incomplete nuclear division and nuclear distortion. The polymorphonuclears from 47% of the patients presented nuclear abnormalities expressed as nuclear bridges, appendices, and blebs. In addition, phagocytosis of red blood cells was observed. The results of the study underline the advantages of the transmission electron microscope examination in visualization of intricate alterations in hematopoietic cells that cannot be detected with a light microscope.

Original languageEnglish
Pages (from-to)155-158
Number of pages4
JournalMicroscopy Research and Technique
Issue number3
StatePublished - 15 Feb 2004


  • Erythroblasts
  • Iron deposits
  • Mitochondria
  • Sideroblastic anemia


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