Ultrastructural basis for different pertechnetate uptake patterns by various human brain tumours

P. Bar-Sella*, D. Front, R. Hardoff, E. Peyser, B. Borovich, I. Nir

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Patterns of pertechnetate uptake were correlated with ultrastructural properties of the endothelial wall in 14 human brain tumours. In tumours with reduced uptake of the radionuclide, intercellular tight junctions were observed whereas absence of intercellular tight junctions was characteristic of all tumours with an increased uptake of pertechnetate. In some tumours with increased uptake, fenestrated endothelial wall was seen while in others nonfenestrated wall was evident. We concluded that intercellular junctions and not fenestrations affect the permeability of brain tumours to pertechnetate.

Original languageEnglish
Pages (from-to)924-930
Number of pages7
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume42
Issue number10
DOIs
StatePublished - 1979
Externally publishedYes

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